Post-Doctoral Position On Llps Structural Analysis

Universities and Institutes of France
December 08, 2022
Contact:N/A
Offerd Salary:Negotiation
Location:N/A
Working address:N/A
Contract Type:Temporary
Working Time:Full time
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  • Organisation/Company: CNRS
  • Research Field: Biological sciences › Biological engineering Chemistry › Biochemistry Physics › Biophysics
  • Researcher Profile: Recognised Researcher (R2)
  • Application Deadline: 08/12/2022 23:59 - Europe/Brussels
  • Location: France › MONTPELLIER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/02/2023
  • The project aims at analyzing the formation of LLPS condensates of TopBP1 in vitro and/or in cellulo. TopBP1 (Topoisomerase IIß-binding protein) is a hub protein in human cells that functions at the crossroad of multiple vital cellular processes and assembles nuclear condensates to switch on ATR signaling (see ref.4).

    Our group at the Center for Structural Biology (CBS) at the University of Montpellier (South of France) offers one open Postdoc position (18 months) to work on lipid-lipid phase separation (LLPS), a new paradigm in cell compartmentalization, using atomic force microscopy (AFM) including high- speed modality (see ref.1) and correlative AFM-fluorescence microscopy (see ref.2-3).

    We are an international team at an interdisciplinary research center with excellent in-house access to state-of-the-art biophysics infrastructure and biochemistry and cell culture facilities. Moreover, several groups at the CBS are working on LLPS, which fosters creativity and collaborations. The research of PE Milhiet's group focuses on the development and use of advanced microscopies (AFM and single molecule fluorescence microscopy) to decipher the molecular mechanisms associated to the organization and remodeling of biological membranes. Our team is pluridisciplinary and counts 15 people including 8 permanent researchers. CBS is an Institute dedicated to research at the forefront of structural biology, biophysics and Bioengineering. It also proposes facilities in these fields. Montpellier is a stunning city on the French Riviera with a significant international research community.

    Eligibility criteria

    The project is highly interdisciplinary, at the interface of biophysics, cell biology and biochemistry. Therefore, successful applicants are expected to have training and research experience in physics/biophysics, especially advanced skills in AFM. Previous experience in fluorescence imaging (confocal/TIRF/Super Resolution/FLIM), Optics as well as biochemistry, cell biology and computation (e.g. Python) skills will be positively considered. The candidates should have a solid publication record (at least one first author paper). Applicants are expected to have defended their PhD thesis within the last 2 years (< 2 years postdoctoral experience).

    Additional comments

    References 1) Nasrallah H. et al. J Mol Biol 1886:45, 2019. 2) A. Vial et al. Nanoscale, 13(29):12484, 2021. 3) T. Fernandes et al. Scientific Reports, 10(1):7098, 2020. 4) Frattini C et al. Mol Cell. 81(6):1231, 2021.

    For more information: "Integrative Biophysics of Membrane" group https: // integrativebiophysicsofmembranes.wordpress.com/ https: // twitter.com/MembranesBiophy

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/CDD/UMR5048-FLOLEP-044/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Chemistry › Biochemistry

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

  • RESEARCH FIELD
  • Physics › Biophysics

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

  • RESEARCH FIELD
  • Biological sciences › Biological engineering

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Chemistry: PhD or equivalent

    Physics: PhD or equivalent

    Biological sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Centre de biologie structurale
  • Organisation Type: Public Research Institution
  • Website: https:// www. cbs.cnrs.fr/
  • Country: France
  • City: MONTPELLIER
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