Post-Doctoral Position In Neuroimmunology

Universities and Institutes of France

France

December 31, 2021

Description

  • Organisation/Company: Centre Immunologie de Marseille-Luminy
  • Research Field: Neurosciences › Neurobiology
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 31/12/2021 23:00 - Europe/London
  • Location: France › marseille
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/08/2021
  • Eu Research Framework Programme: H2020 / ERC
  • Team: Immunosurveillance of the Central Nervous System

    https:// www. ciml.univ-mrs.fr/science/lab-rejane-rua/immunosurveillance-ce...

    Group leader: Rejane RUA

    Centre d'Immunologie Marseille-Luminy

    163 avenue de Luminy 13288 Marseille, France

    Mail: rua@ciml.univ-mrs.fr

    Phone: +33 4 91 26 94 35

    Post-doctoral position in NeuroImmunology

    ‘Unravelling the neuroprotective roles of macrophages at the brain surface'

    3 to 5 years, starting August/September 2021

    The surface of the Central Nervous System (CNS) is connected to the periphery by layers of highly vascularized membranes, the meninges. Although the brain has been considered immunoprivileged for decades, it has been recently shown by our team and others that the meninges are populated by a myriad of resident immune sentinels. Unexpectedly, immune cells specifically located in the meninges play a role in neuronal function, tissue homeostasis as well as infectious, inflammatory and age-related neurodegenerative diseases. Due to their strategic location at the interface between the periphery and the brain, the meninges thus function as a nurturing tissue enveloping the CNS and also represent its first line of protection.

    Even though meningeal macrophages represent the most promising candidates involved in CNS function and dysfunction due to their abundance and location, virtually nothing is known about their properties. The objective of this project is to understand how macrophages at the brain surface maintain neuronal functions.

    We hypothesize that meningeal macrophages are heterogeneous and that distinct macrophage subpopulations differ in the magnitude and quality of their pro- neuronal functions. To address these questions, we will combine multiparametric flow cytometry, state-of-the-art single-cell transcriptomics, CRISPR-Cas9 technology, stereotactic injections and intravital imaging approaches to analyze the heterogeneity and functions of meningeal macrophages in wild-type and transgenic mouse models.

    The candidate must have a PhD in immunology, virology or neuroscience. Experience with Crispr/Cas9 gene editing, AAV, stereotactic injections, neuronal tracing, nucSeq RNAseq and/or optogenetics is appreciated.

    Applications should be sent to rua@ciml.univ-mrs.fr.

    Selection of recent publications

    1. Rua R, et al. Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity. Nat Immunol. 2019

    2. Rua R, McGavern DB. Advances in Meningeal Immunity. Cell Press Trends Mol Med. 2018

    3. Kwong B, Rua R et al. T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation. Nat Immunol. 2017

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

    Skills/Qualifications

    The candidate must have a PhD in immunology, virology or neuroscience. Experience with Crispr/Cas9 gene editing, AAV, stereotactic injections, neuronal tracing, nucSeq RNAseq and/or optogenetics is appreciated.

    Contact Information
  • Organisation/Company: Centre Immunologie de Marseille-Luminy
  • Department: Inserm U1104 - CIML
  • Organisation Type: Public Research Institution
  • Website: https:// www. ciml.univ-mrs.fr/fr/science/lab-philippe- pierre/pour-les-experts
  • Country: France
  • City: Marseille cede 9
  • State/Province: case 906
  • Postal Code: 13288
  • Street: Parc scientifique de Luminy
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