Post-doctoral neuronal cell biologist: “Functional CRISPRi screening of
Parkinson's genes in human iPSC neurons”
Department of Physiology, Anatomy and Genetics, Kavli Institute for
Nanoscience Discovery, South Parks Road, Oxford
Grade 7: £32,817 – £40,322 p.a.
Applications are invited for a post-doctoral neuronal cell biologist to work
on a research project at the Oxford Parkinson's Disease Centre (OPDC) to
functionally identify new genes underlying Parkinson's disease.
This is an exciting opportunity to undertake CRISPRi functional screening in
induced pluripotent stem cell (iPSC)-derived dopamine neurons. This project
will undertake a functional analysis of GWAS loci to identify new genes
underlying the cellular pathology of Parkinson's, focused on the endolysosomal
system to better understand the molecular mechanisms of the disease.
Duties include design and implementation of experiments; interpretation of
data; design, generation and use of CRISPRi technology; high-content imaging
analysis; differentiation and analysis of iPSC-derived neurons and cell lines;
preparation of data for publication; contribute ideas for new research
projects and develop ideas for generating research income; manage own academic
research involving small-scale project management and act as a source of
information to other members of the group.
You will have excellent practical experience of working with cell cultures,
preferably using iPSC models or neurons, and a good knowledge of cellular
models of neurodegenerative disease. The ability to innovate, trouble-shoot
technical problems, be meticulous in practical work and in record keeping is
also essential. Applicants must hold, or be near completion of, a PhD/DPhil in
a relevant area of research and have experience in cellular neuroscience, and
molecular cell biology relevant to analysis of neuronal phenotypes.
The post is available immediately until 30th June 2024. The post will be based
in the Laboratory of Molecular Neurodegeneration, Kavli Institute for
Nanoscience Discovery, South Parks Road, Oxford.
Informal enquiries may be directed Professor Richard Wade-Martins
Closing date for applications is midday on Tuesday 13th July 2021.
Interviews are likely to be held on the week beginning 19th July 2021.
Applications are particularly welcome from women, black and minority ethnic
candidates who are under-represented in academic posts in Oxford.
We, as a Department and Community, will be considerate and welcoming of all
people, regardless of race, ethnicity, religion, disability, sexual
orientation and gender identity. We acknowledge societal inequalities and how
these impact us, and those around us, personally and professionally. – DPAG
Statement of Inclusion
Contact Person : HR Team Vacancy ID : 151569
Contact Phone : Closing Date & Time : 13-Jul-2021 12:00
Contact Email : email@example.com