A post-doc position founded by Pfizer through a Global Medical Grant is
available at the University of Udine (Italy) in the Biophysics lab of Prof.
The successful candidate will study the effect of shear forces on the
amyloidogenic protein transthyretin (TTR) by NMR. The project arises in the
framework of the mechano-enzymatic amyloidogenesis model proposed for TTR
amyloidosis (ATTR) and aims to elucidate the role of mechanical forces in
the proteolytic event leading to protein aggregation at the molecular level.
Rheo-NMR will be used to investigate these processes at atomic resolution. In
addition, interaction with mono- and bi-valent TTR stabilizers will be
elucidated. The post-doc is expected to carry out solution state NMR
experiments with a focus on protein structure and dynamics.
The work will be carried out in collaboration with the Amyloid Unit Research
at the University of Pavia and the Centre for Amyloidosis and Acute Phase
Proteins at University College London.
The initial appointment is for one year starting from 1 December 2022, with
the possibility of renewal.
The applicant should be highly motivated and have a strong background in
protein NMR spectroscopy.
Applicants must submit before 30 September a cover letter summarizing research
experience, a CV (including a publication list) and two reference contacts
to firstname.lastname@example.org and email@example.com.