Post doc position in experimental studies on Intrinsically Disordered Protein Interactions available within REPIN – Rethinking Protein Interactions

Copenhagen University

Denmark

September 1, 2021

Description

REPIN, Department of Biology, Faculty of Science, University of Copenhagen, has an open post doc position available from November 1st, 2021, or soon thereafter. The position is part of the Novo Nordisk Foundation Challenge Center REPIN- rethinking protein interactions. REPIN connects research groups in Copenhagen and Zürich to study interactions of Intrinsically Disordered Proteins (IDPs) using a suite of biophysical methods and ranging from the single atom and molecule, over ensembles to organisms.

A post doc position (2 years with the possibility of extension) will be available to study how context influences the interactions of IDPs driven by short liner motifs ( SLIMs ). Focus will be on how context in terms of chain properties (length, compaction and dynamics), when tethered to folded domains and when engaging in higher order complexes incl. liquid-liquid phase separation processes impact affinity, kinetics and thermodynamics in SLiM- based binding. Two systems are selected for the studies playing key roles in DNA replication and transcription with relevance to human diseases and plant quality, and the candidate will be responsible for deciding on a third, relevant model system.

The postdoctoral fellow will work in the groups of Birthe B. Kragelund and Karen Skriver located in the Department of Biology in central Copenhagen. In addition to being founding laboratories of REPIN, the groups are members of the interdisciplinary and collaborative research environment at the Linderstrøm-Lang Centre for Protein Science. The postdoctoral fellow will work together with scientists from a number of disciplines, and engage in collaboration with other partner laboratories within REPIN. The groups are highly international and a good level of spoken and written English is essential.

Qualifications:

We are seeking highly motivated and strong applicants with a PhD degree in chemistry, biophysics, biochemistry or similar fields, and with previous publications in peer-reviewed scientific journals and prior research experience within or with

  • Integrative structural biology
  • Protein folding and interactions
  • Biophysical studies of IDPs
  • Biophysical techniques as ITC, stopped-flow, CD, protein NMR spectroscopy or small angle X-ray scattering
  • It will be advantageous to also have experience with one or both of the following:

  • Molecular dynamics
  • Liquid-liquid phase separation
  • The postdoc's duties will include research within IDPs as well as teaching and supervision. The post may also include other duties.

    Further information on the Department is linked at https: // www. science.ku.dk/english/about-the-faculty/organisation/.

    For further information about the position, please contact Professors Karen Skriver (kskriver@bio.ku.dk) or Birthe B. Kragelund (bbk@bio.ku.dk)

    The position is open from 1 November 2021 or as soon as possible thereafter.

    The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

    Terms of employment

    The position is covered by the Memorandum on Job Structure for Academic Staff.

    Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

    The starting salary is currently up to DKK 440.935 including annual supplement (+ pension up to DKK 75.399). Negotiation for salary supplement is possible.

    The application, in English, must be submitted electronically by clicking APPLY NOW below.

    Please include

  • Curriculum vitae
  • Diplomas (MSc and PhD degree or equivalent)
  • Complete publication list with indication of the candidate's contribution
  • Separate reprints of 3 particularly relevant papers
  • The deadline for applications is 1st September 2021 23:59 GMT +2

    After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

    You can read about the recruitment process athttps: // employment.ku.dk/faculty/recruitment-process/ .

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