A Post Docotral position (initial funding is for 1 year but funding for renewal is available) is open in the team
of Bénédicte DELAVAL at the CRBM (Montpellier cell Biology Research Center). The CRBM
(https: // www. crbm.cnrs.fr) is a research institute located in Montpellier, Southern France, internationally
renowned for its research in cell and developmental biology. The institute covers fundamental aspects of cell
biology and is located on the interdisciplinary campus of the French National Centre for Scientific Research
(CNRS) and is connected to the university of Montpellier. The Institute therefore provides an international and
multidisciplinary research environment, as well as access to core facilities (Biocampus: microscopy MRI ;
zebrafish and xenopus ZEFIX) to ensure the successful development of the research.
The DELAVAL Team, Centrosome Cilia and Pathologies addresses emerging questions in the field of cell
biology and epithelial tissue morphogenesis focusing on the contribution of highly dynamic cellular processes
such as cell division. More specifically, we are studying, from the molecular to the tissue scale how
intracellular transport complexes (proteins of the IntraFlagellar Transport machinery, IFT) involved in kidney
pathologies control the geometry of cell division. We also focus our interest on understanding how cell division
contributes to kidney tubule morphogenesis under normal and pathological conditions. To address these
questions we combine in the team cell biology and microscopy approaches on complementary systems going
from single molecules in vitro and 2D/3D cell culture to zebrafish as an in vivo model.
Main missions :
The candidate will study the contribution of cell division, and more specifically its last stage cytokinesis, to
kidney epithelial tubule organization using primarilly zebrafish embryos. The zebrafish pronephros is used in
this project as a simplified vertebrate model to study live and in vivo the impact of cell division perturbations
on kidney tubule organization under normal and pathological conditions (IFT mutants). We are looking for a
postdoctoral scientist with a solid background in cell biology, microscopy and image analysis interested in
interdisciplinary approaches on multicellular systems (3D culture systems, zebrafish embryos…). This project
and position are funded by the “Fondation pour la Recherche Médicale”. The candidate will work under the
supervision of Bénédicte DELAVAL and will interact with an engineer and an assistant professor in the team for the technical implementations.
The candidate will be in charge of his research project including:
-zebrafish and 3D cell culture experimentation
-implementation and development of imaging appraoches to study cell division in the zebrafish pronephros
under normal and perturbed conditions (spinning disk live imaging, high content screening…)
-characterization of the contribution of cytokinesis geometry defects to kidney cyst initiation (experimental
design, experimentation, results ananlysis)
-implementation of automated image ananlysis (interaction with MRI analysis platform)
-result analysis and presentation of the project
On-site learning of specific complementary skills will be available:spinning disk confocal imaging, zebrafish…Eligibility criteria
The applicant should be a researcher holding a PhD degree in molecularSelection process
Send your CV and cover letter by email to : benedicte.delavalrbm.cnrs.fr before 12/21/2022.Offer Requirements Skills/Qualifications
The applicant should be a researcher holding a PhD degree in molecular, cell and/or developmental biology.
He/she should have solid experimental skills in cell/developemental biology, live imaging, image analysis as
well as a strong interest in cell division and cytoskeleton biology.
Experience with cell division in cellular or developmental models (in vivo models, multicellular systems…) will
be very positively considered.
Experience with zebrafish as an in vivo model organism will be positively considered but is not mandatory.
The applicant should be highly motivated, curious and enthusiastic to work on a interdisciplinary and
collaborative project.Contact Information