Post-Doc In Position In Cell/Developmental Biology

Universities and Institutes of France
December 21, 2022
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Offerd Salary:Negotiation
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Contract Type:Temporary
Working Time:Full time
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  • Organisation/Company: Universite de Montpellier
  • Research Field: Biological sciences › Biology
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 21/12/2022 22:00 - Europe/Brussels
  • Location: France › montpellier
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 38
  • Offer Starting Date: 03/01/2023
  • Eu Research Framework Programme: HE
  • Reference Number: 2022- R0494
  • A Post Docotral position (initial funding is for 1 year but funding for renewal is available) is open in the team

    of Bénédicte DELAVAL at the CRBM (Montpellier cell Biology Research Center). The CRBM

    (https: // www. crbm.cnrs.fr) is a research institute located in Montpellier, Southern France, internationally

    renowned for its research in cell and developmental biology. The institute covers fundamental aspects of cell

    biology and is located on the interdisciplinary campus of the French National Centre for Scientific Research

    (CNRS) and is connected to the university of Montpellier. The Institute therefore provides an international and

    multidisciplinary research environment, as well as access to core facilities (Biocampus: microscopy MRI ;

    zebrafish and xenopus ZEFIX) to ensure the successful development of the research.

    The DELAVAL Team, Centrosome Cilia and Pathologies addresses emerging questions in the field of cell

    biology and epithelial tissue morphogenesis focusing on the contribution of highly dynamic cellular processes

    such as cell division. More specifically, we are studying, from the molecular to the tissue scale how

    intracellular transport complexes (proteins of the IntraFlagellar Transport machinery, IFT) involved in kidney

    pathologies control the geometry of cell division. We also focus our interest on understanding how cell division

    contributes to kidney tubule morphogenesis under normal and pathological conditions. To address these

    questions we combine in the team cell biology and microscopy approaches on complementary systems going

    from single molecules in vitro and 2D/3D cell culture to zebrafish as an in vivo model.

    Main missions :

    The candidate will study the contribution of cell division, and more specifically its last stage cytokinesis, to

    kidney epithelial tubule organization using primarilly zebrafish embryos. The zebrafish pronephros is used in

    this project as a simplified vertebrate model to study live and in vivo the impact of cell division perturbations

    on kidney tubule organization under normal and pathological conditions (IFT mutants). We are looking for a

    postdoctoral scientist with a solid background in cell biology, microscopy and image analysis interested in

    interdisciplinary approaches on multicellular systems (3D culture systems, zebrafish embryos…). This project

    and position are funded by the “Fondation pour la Recherche Médicale”. The candidate will work under the

    supervision of Bénédicte DELAVAL and will interact with an engineer and an assistant professor in the team for the technical implementations.

    Activities :

    The candidate will be in charge of his research project including:

    -zebrafish and 3D cell culture experimentation

    -implementation and development of imaging appraoches to study cell division in the zebrafish pronephros

    under normal and perturbed conditions (spinning disk live imaging, high content screening…)

    -characterization of the contribution of cytokinesis geometry defects to kidney cyst initiation (experimental

    design, experimentation, results ananlysis)

    -implementation of automated image ananlysis (interaction with MRI analysis platform)

    -result analysis and presentation of the project

    On-site learning of specific complementary skills will be available:spinning disk confocal imaging, zebrafish…

    Eligibility criteria

    The applicant should be a researcher holding a PhD degree in molecular

    Selection process

    Send your CV and cover letter by email to : benedicte.delavalrbm.cnrs.fr before 12/21/2022.

    Offer Requirements Skills/Qualifications

    The applicant should be a researcher holding a PhD degree in molecular, cell and/or developmental biology.

    He/she should have solid experimental skills in cell/developemental biology, live imaging, image analysis as

    well as a strong interest in cell division and cytoskeleton biology.

    Experience with cell division in cellular or developmental models (in vivo models, multicellular systems…) will

    be very positively considered.

    Experience with zebrafish as an in vivo model organism will be positively considered but is not mandatory.

    The applicant should be highly motivated, curious and enthusiastic to work on a interdisciplinary and

    collaborative project.

    Contact Information
  • Organisation/Company: Universite de Montpellier
  • Department: Human Resources
  • Organisation Type: Higher Education Institute
  • Website: https:// www. umontpellier.fr/
  • E-Mail: benedicte.delaval@crbm.cnrs.fr
  • Country: France
  • City: Montpellier
  • Postal Code: 34000
  • Street: 163 rue Auguste Broussonnet
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