Post-Doc In Evolutionary Genomics - Evolution Of Gene Expression (M/F)

Universities and Institutes of France
December 09, 2022
Offerd Salary:Negotiation
Working address:N/A
Contract Type:Temporary
Working Time:Full time
Working type:N/A
Job Ref.:N/A
  • Organisation/Company: CNRS
  • Research Field: Biological sciences Environmental science
  • Researcher Profile: Recognised Researcher (R2)
  • Application Deadline: 09/12/2022 23:59 - Europe/Brussels
  • Location: France › RENNES
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/02/2023
  • - Development of an analysis pipeline allowing to make the link between annotation of deleterious mutations and specific allele expression - Application to publicly available data - Make the tools developed available for the other partners of the project - Dissemination of results in the form of articles and presentation at conferences

    The objective is to test a new theory on the evolution of the regulation of gene expression. The post-doc will set up a genomic pipeline to test the predictions of this theory, apply it to datasets already available in public databases and test the effect of certain parameters of the theory such as recombination or reproductive systems.

    The researcher will work within the framework of the ANR CisTransEvol project, the objective of which is to study the evolution of the regulation of gene expression in eukaryotes using evolutionary genomics approaches. More specifically, the objective is to test a theory recently proposed by the project leader on the evolution of cis-regulators of gene expression ("run- away evolution"). A key element of this theory that will be tested is the existence of an association between allelic expression bias (determined by cis regulators) and deleterious mutations in the coding regions of genes. Fyon, F., A. Cailleau, and T. Lenormand. 2015. Enhancer Runaway and the Evolution of Diploid Gene Expression. PLOS Genetics 11:e1005665.

    The recruited person will work within the scientific theme "Evolution of genomes, life history traits and adaptation" within the UMR 6553 ECOBIO under the responsibility of Sylvain Glémin (DR CNRS), partner of the ANR CisTransEvol project. He/she will work partly with the tools and the support of the genouest platform. He/she will be required to travel to Montpellier and Roscoff for meetings with project partners and to France or abroad for scientific conferences.

    Eligibility criteria

    - PhD in evolutionary biology/genomics - Knowledge of bioinformatics techniques for processing genomic data - Programming experience for genomic data analysis (R, Python) - Experience in using computer clusters - Experience in the use of genomic databases and the processing of massive and heterogeneous datasets - Ability to work in a team - English level B2 to C1, be able to write and present scientific articles

    Web site for additional job details

    https: //

    Required Research Experiences
  • Biological sciences

  • 1 - 4

  • Environmental science

  • 1 - 4

    Offer Requirements
  • Biological sciences: PhD or equivalent

    Environmental science: PhD or equivalent

  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Écosystèmes, biodiversité, évolution
  • Organisation Type: Public Research Institution
  • Website: https://
  • Country: France
  • City: RENNES
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