Post Doc in Cellular Tomography
Job ID 2619 Date posted 01/07/2022
Brookhaven National Laboratory (www. bnl.gov) delivers discovery science and
transformative technology to power and secure the nation's future. Brookhaven
Lab is a multidisciplinary laboratory with seven Nobel Prize-winning
discoveries, 37 R&D 100 Awards, and more than 70 years of pioneering research.
The Lab is primarily supported by the U.S. Department of Energy's (DOE)
Office of Science. Brookhaven Science Associates (BSA) operates and manages
the Laboratory for DOE. BSA is a partnership between Battelle and The Research
Foundation for the State University of New York on behalf of Stony Brook
The mission in the Biology Department at Brookhaven National Laboratory seeks
to unravel and fully describe the complexities of biological systems - from
how plants make oils and other products to the role of proteins in disease.
The Brookhaven National Laboratory has openings for Postdoctoral Research
Associates to carry out technology development and scientific research
projects in the area of imaging biological processes to understand biological
complexity for bioenergy. Scientific topics of the project include, but not
limited to, metal homeostasis and stress resistance, lipid biosynthesis and
metabolism, plant-microbe interactions, and plant cell wall structure and
biosynthesis. The incumbents will work closely with scientists from the
Biology Department, National Synchrotron Light Source II (NSLS-II),
Laboratory for BioMolecular Structure (LBMS) Cryo-EM facility, Computational
Science Initiative (CSI) as well as Yale University. The positions are two-
year term and may be extended to three years contingent upon satisfactory
performance and continued funding.
This project will utilize the state-of-the-art Brookhaven Lab facilities NSLS-
II on X-ray imaging, CFN (Center for Functional Nanomaterials) on light
microscopy, LBMS on electron tomography, and CSI on advanced computational
infrastructure and algorithms. NSLS-II is a world-leading synchrotron facility
that produces high-flux, and low-emittance X-rays for solving a wide range of
biological problems via diffraction, scattering, and imaging capabilities. CFN
explores the unique properties of materials and processes at the nanoscale
supported by the operation of high-end instruments from material fabrication
and characterization to theory and computation. LBMS provides imaging
capabilities for studying biological structures and processes at sub-nanometer
resolutions. The integration of lights, x-rays, and electrons as imaging tools
will allow for studying transient biological structures and processes at an
BNL offers competitive compensation commensurate with relevant experience and
qualifications. Candidates should submit a CV, a brief description of research
interests, and contact information for three references.
Essential Duties and Responsibilities:
Prepare biological tissues and cellular samples for imaging data
acquisition and analysis.
Develop sample handling tools and protocols for integrated multi-scale
imaging data acquisition using light microscopy, x-ray and electron
Develop optimized methods and procedures to mill tissue and cell samples
for electron tomography.
Document and disseminate research results through publications and
Required Knowledge, Skills, and Abilities:
Ph.D. in biophysics, chemistry, biochemistry, physics, bioengineering,
plant biology, cell biology, or a related field.
Demonstrated experience in one or more of tissue/cell culture, gene
expression, cellular and tissue imaging, instrumentation for bioimaging,
imaging data acquisition, and image data analysis.
Demonstrated publication record in a peer-reviewed journal.
Excellent oral and written communication skills and effective interaction
in a team environment.
Preferred Knowledge, Skills, and Abilities:
Experience in using a confocal light microscope such as Leica TCS SP5 and
Familiar with x-ray diffraction or imaging data acquisition at a
Experience in using a transmission electron microscope such as Titan
Krios, Talos and JEM2100F.
Experience in the development of instruments and protocols toward
Skills in shell scripting and programming.
Experience in using a cryoFIB for electron tomography.
Experience in gene expression in mammalian cells, Tabacco leaves,
Arabidopsis, or other land plants.
Ability to communicate effectively and diplomatically.
BNL policy requires that research associate appointments be made to
individuals who have received their doctorate within the past five years.
At Brookhaven National Laboratory we believe that a comprehensive employee
benefits program is an important and meaningful part of the compensation
employees receive. Our benefits program includes, but is not limited to:
Paid Parental Leave
Swimming Pool, Weight Room, Tennis Courts, and many other employee perks
Brookhaven Science Associates requires proof of a COVID-19 vaccination for all
employees. Proof of full vaccination as recognized by the CDC and/or WHO,
inclusive of the two-week waiting period, is required at the start of your
Brookhaven National Laboratory (BNL) is an equal opportunity employer that
values inclusion and diversity at our Lab.We are committed to ensuring that
all qualified applicants receive consideration for employment and will not be
discriminated against on the basis of race, color, religion, sex, sexual
orientation, gender identity, national origin, age, status as a veteran,
disability or any other federal, state or local protected class.
BNL takes affirmative action in support of its policy and to advance in
employment individuals who are minorities, women, protected veterans, and
individuals with disabilities.We ensure that individuals with disabilities are
provided reasonable accommodation to participate in the job application or
interview process, to perform essential job functions, and to receive other
benefits and privileges of employment.Please contact us to request
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Foreign Government Talent Recruitment Programs, as defined and detailed in
United States Department of Energy Order 486.1A. You will be asked to disclose
any such participation at the time of hire for review by Brookhaven. The full
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