PhD studentship - Sara Zanivan 2023

Cancer Research UK
January 06, 2023
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Offerd Salary:£21,000
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Job details

Job title

PhD studentship - Sara Zanivan 2023

Job reference

REQ00242

Date posted

22/11/2022

Application closing date

06/01/2023

Location

Glasgow

Salary

Stipend - £21,000

Package

All tuition fees will be covered

Contractual hours

Blank

Basis

Blank

Job category/type

PhD Students

Attachments

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Job description

Tumour microenvironment and metabolism

The tumour microenvironment (TME) has a fundamental role in promoting tumour development, metastasis, and response to therapy. Cancer associated fibroblasts densely populate the TME, and our group and others have shown that they facilitate tumour progression by secreting a multitude of factors, including extracellular matrix (ECM), chemokines and metabolites, that alter the TME and influence the behaviour of cancer cells and blood vessels (Kay et al. Nat Metab 2022, Kugeratski et al. Sci Signal 2019, Hernandez-Fernaud et al. Nat Commun 2017, Reid et al. EMBO J. 2017). More recently, it has emerged that CAFs are central players also in immune regulation. Despite the key roles played by CAFs in cancer, the molecular mechanisms that underpin their functions are not yet fully understood. This project aims to tackle this question to find ways to target CAFs to oppose tumour-promoting functions of the TME in triple negative breast cancer and ovarian cancer. Both tumour types are highly aggressive and are in urgent need of new effective therapies.

Altered cell metabolism is a hallmark of cancer, and we now know that also the metabolism of the fibroblasts is altered in tumours (Kay et al. Curr Opin Syst Biol 2021). We have recently found that there are specific metabolic pathways in CAFs that are central to support the production of tumour- and metastasis-promoting ECM in breast cancer (Kay et al. Nat Metab 2022). With this project we aim to mechanistically dissect the consequences of targeting specific metabolic pathways in CAFs on cancer and immune cell functions important to support tumour malignancy, and the potential of targeting CAFs together with other anti-cancer therapies to effectively eradicate tumours.

The student will use in vitro culture systems and in vivo models of breast or ovarian cancer already established in the Zanivan group in combination with knock-out and over-expression techniques and state-of-the art omics technologies including, mass spectrometry (MS)-based proteomics and metabolomics.

For informal enquiries, please contact Prof Sara Zanivan (sara.zanivan@glasgow.ac.uk)

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