Phd Student Working On Telomere Biology

Universities and Institutes of France

France

October 3, 2022

Description

  • Organisation/Company: CNRS
  • Research Field: Biological sciences › Biology
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 03/10/2022 23:59 - Europe/Brussels
  • Location: France › MONTPELLIER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/11/2022
  • The student will be working in the Biology of repetitive sequences lab, under the supervision of Jerome DEJARDIN. Website: https: // www. igh.cnrs.fr/en/research/departments/genome- dynamics/biologie...

    Mammalian telomeres are composed of a tandem array of specific DNA motifs, to which a dedicated set of factors named shelterin proteins specifically bind. Shelterin proteins regulate telomere replication, their length control and critically, their protection. Telomere Repeat binding Factor 2 (TRF2) is a shelterin which specifically binds to telomeric DNA. TRF2 is involved in the formation of the telomere-loop (T-loop), a crucial terminal structure in which the single stranded telomere DNA overhang stably invades the duplex telomeric DNA. This structure prevents telomeres from being recognized as mere double strand breaks and aberrantly fused by non-homologous end-joining activities. Thus, in the absence of TRF2, telomeres become the substrate of DNA repair activities which lead to spectacular “trains” of chromosome fused through their telomeres. How TRF2 enforces T-loop formation is only partly understood, but TRF2 is viewed as a central telomere component required to protect telomeres in all tissues. Yet, recent work has demonstrated that TRF2, while present on telomeres, is dispensable for telomere protection and T-loop formation in embryonic stem cells and earlier pre-implantation stages. This surprising result suggests that other factors/mechanisms are involved in telomere protection in these contexts. We have identified a previously uncharacterized protein which binds telomeres in early embryos. In the absence of TRF2, the loss of this protein leads to strong DNA damage response at telomeres and telomere fusions. We propose to study the function of this protein with in vivo as well as in vivo approaches. As telomeres are key controllers of the replicative potential of cells and of chromosome stability, it is central to understand the mechanistic underpinnings of their protection, as this could lead to advances in cancer or anti-aging therapy.

    Additional comments

    N/A

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/Doctorant/UMR9002-JERDEJ-004/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences › Biology

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut de Génétique Humaine
  • Organisation Type: Public Research Institution
  • Website: https:// www. igh.cnrs.fr/
  • Country: France
  • City: MONTPELLIER
  • Similar Jobs

    Add to favorites Read more...

    Postdoc In Telomere Biology (M/F)

    Research Field: Biological sciences › Biology extractions, and analyzes of nucleic acids and proteins) - Cell Biology the pathways causing replicative senescence induced by telomere length erosion and senescence to uncover the molecular basis of...

    Add to favorites Read more...

    Mechanisms Of Complement Activation In Cancer: Role Of The Lectin Pathway

    lectin pathway in mouse models of cancer and metastasis using gene targeted lectin pathway activation and complement deposition using in vitro approaches; c) the relevance of this pathway through pharmacological targeting; d) its Eligible destination...

    Add to favorites Read more...

    Post-Doc

    Research Field: Biological sciences › Biology Location: Greece › Heraklion The mitotic spindle is a microtubule-based apparatus that is responsible Defects in spindle formation can novel phosphorylation sites on tubulin, which are essential for optimal...

    Add to favorites Read more...

    Post-Doctoral Position In Mitochondrial Stress & Mitonuclear Communications

    Research Field: Biological sciences › Biology year) is available in January 2023 within Dr. Damien Arnoult's laboratory at the mitochondrial stress and the mitonuclear communications. to environmental stresses that affect mitochondrial function. Recently, an OMA1-DELE1-HRI...

    Institut Pasteur

    France 2 days ago

    Add to favorites Read more...

    Post-doc position in early development and pluripotent stem cells

    2022) with experience in developmental biology and working with early mouse mechanisms of action of a neglected class of developmental regulators, orphan nuclear receptors, during zygotic genome activation (ZGA), early lineage which orphan nuclear receptors...