Chronic exposure of the general population to complex mixtures of chemicals is
suspected of contributing to many adverse health outcome such as non-
communicable chronic diseases (NCD) which are the major causes of premature
death worldwide. Hence, deciphering the human chemical exposome (i.e.
characterizing chemical mixtures and their transformation products accumulated
in human biological matrices) and identifying the relevant chemical mixtures
associated with NCDs would be a key step towards improving health and
potentially reduce the overall burden of NCDs.
To this aim, innovative holistic methodologies methods are acutely needed to
make a step change in human exposure assessment and capture the high diversity
of exposures human is facing daily. Importantly, many NCDs could have their
origins in utero (developmental origins of health and disease – DOHaD); it
is therefore essential to focus on one of the most critical and vulnerable
periods of development, i.e. the prenatal period.
The main objective of PhD will be to develop a robust standardized methodology
to apply suspect screening and non-targeted analyses based on high-resolution
mass spectrometry (HRMS) to profile placenta samples from mother-child
cohort studies. Profiling placenta using untargeted methods offers many
advantages to monitor fetal exposure as many xenobiotics have been shown to
accumulate over time in the placenta.
Funding category: Financement de l'Union européenne
PHD Country: France
Offer RequirementsSpecific Requirements
We seek a highly motivated and enthusiastic candidate with a master degree in
analytical chemistry and initial expertise in the area of HRMS-based
exposomics, metabolomics, or analytical chemistry. Essential skills for this
job include experience in biological sample preparation techniques; practical
expertise in liquid chromatographic methods and/or gas chromatography.
Organisation/Company: Ecole des Hautes Etudes en Santé Publique EHESP