A central question in the origin of life is how evolution could have emerged in physical-chemical systems. RNA is an experimental model for the prebiotic world because RNA is both an information carrier and a catalyst. RNAs derived from group I introns have been shown to self-reproduce from smaller fragments, recombine other RNAs, and produce novel ribozymes. Therefore, RNA is a highly promising model to build an artificial reactions networks capable of evolution. However, a system made of RNA and capable of evolution remains to be discovered.
The project aims to build novel in vitro RNA ribozymes capable of self- reproduction. We will use high-throughput screens of catalytic activities, directed evolution, rational design, in close collaboration with computer modelling.Web site for additional job details
https: // www. lbe.espci.frRequired Research Experiences
1 - 4Offer Requirements
Biological sciences: PhD or equivalent
Given the highly interdisciplinary nature of these projects, candidates from diverse backgrounds will be considered: Molecular biology, RNA biochemistry, Experimental evolution.Specific Requirements
In any case, the candidate should have a strong motivation to learn novel techniques, concepts and to team work in an interdisciplinary environment.Contact Information