Open Positions 1
Time Span as soon as possible for 3 years
Application Deadline 13 Sep 2022
Type of Position
PhD - Individual Supervisor
Field of Research
Mathematics / Natural Sciences
Subjects Functional Genomics
Description Founded in 1607, Justus Liebig University Giessen (JLU) is
a research university rich in tradition. Inspired by curiosity about the
unknown, we enable around 28,000 students and 5,700 employees to advance
science for society. Join us in breaking new ground and writing success
stories - your own and those of our university.
Support us as of now in part-time (65 %) as a
PhD student (m/f/d) / Research Associate (m/f/d) - Role of SOCS1 Mutations
in B Cell Lymphomas
The position is part of the externally funded project „The Role of SOCS1
Mutations in the Pathogenesis of Hodgkin Lymphomas and Diffuse Large B Cell
Lymphomas” and is to be filled on a fixed-term basis in accordance with § 2
WissZeitVG and § 72 HessHG with the opportunity for own academic qualification
at the Professorship for Cytology with focal point of lymphoproliferative
Diseases, Department of Pathology at the Faculty of Medicine. The salary is in
accordance with the collective labour agreement of the State of Hessen (E 13
As long as the maximum permissible duration of a fixed-term contract is not
exceeded, you will be employed for a period of 3 years.
While cancer genome sequencing studies have mapped the mutational landscape of
many B-cell lymphomas, it remains a challenge to identify and understand the
functional oncogenic events that drive the genesis and survival of these
malignant neoplasms. However, recent biotechnological advances are enabling
functional genomics experiments on a scale that can match the pace of genome
sequencing. Numerous findings from these studies form the basis for
translational approaches in modern oncology for the development of new
therapies and prognostic biomarkers.
SOCS1 is mutated in germinal center B cell derived lymphomas with significant
differences in prevalence and mutation pattern between diverse lymphoma
subgroups. A recent study demonstrated that SOCS1 inactivation in cultured
germinal center B cells causes immortalization of these cells. We aim to
perform a comprehensive investigation on the role of SOCS1 mutations in the
pathogenesis of B Cell Lymphomas.
Your tasks at a glance
• Explore the molecular phenotype of primary cultured human GC B cells induced
by SOCS1 inactivation
• Characterize the functional significance of various SOCS1 mutations
• Investigate signaling pathways that act synergistically to SOCS1 mutations
The provision of academic services (including the processing of a research
project financed by third party funds on a temporary basis) also serves the
purpose of academic qualification.
Your qualifications and competences
• University degree (MSc.) in a relevant subject (biology, life sciences,
molecular medicine, etc.)
• Strong background in tissue culture and molecular biology techniques such as
cloning, PCR, etc.
• Strong motivation, scientific curiosity and commitment to scientific
• Very good verbal and written English communication skills are expected
Our offer to you
• A scientific project in the field of translational cancer research
• Opportunity to learn and apply a wide array of state-of-the-art functional
methods such as CRISPR/Cas9 screenings, high throughput sequencing techniques
(RNAseq, ChIPseq, ATACseq), competitive gain-of-function ORF screens, etc.
• Excellent mentoring by PI and PostDocs and support in the development of
your scientific profile
• Active participation in the International Giessen Graduate Centre for the
Life Sciences providing seminars, practical courses, research retreats and
essential skills for academic and business careers in life sciences
(https: // www. uni-giessen.de/fbz/zentren/ggl)
• Free use of local public transport (LandesTicket Hessen)
• More than 100 training seminars, workshops and e-learning opportunities per
year for personal development, as well as a wide range of health and sports
• Remuneration according to TV-H, company pension scheme, child allowance and
• Good compatibility of family and career (certificate "audit
If you have any further questions, please do not hesitate to contact Prof. Dr.
rer. nat. Roland Schmitz by e-mail (firstname.lastname@example.org-
The JLU aims to employ more woman in academic research. We therefore
particularly encourage female candidates to apply. The JLU is regarded as a
family-friendly university. Applicants with children are very welcome.
Applications from disabled people of equal aptitude will be given preference.
You want to break new ground with us?
Apply by September 13th, 2022, indicating reference number 520/11 via our
https: // www. uni-giessen.de/karriere/stellenangebote/application
Applications should include a one page cover letter describing your research
goals, interest, and motivation together with a recent curriculum vitae (CV)
including publications. We look forward to receiving your application.
Language of Dissertation
Letter of Motivation
List of Publication
More Information https: // www. uni-