19.01.2023PhD Student (m/f/d) Cellular Parasitology Bernhard-Nocht-Institut für Tropenmedizin (BNITM), Hamburg
The Bernhard Nocht Institute for Tropical Medicine (www. bnitm.de) is the largest Research Institute for Tropical Medicine in Germany and is the National Reference Centre for Tropical Pathogens, a WHO Collaborating Centre and member of the Leibniz Research Association.
The group of Dr. Joachim Michael Matz at the Department of Cellular Parasitology of the Bernhard Nocht Institute for Tropical Medicine in Hamburg is looking for a highly motivated
PhD Student (m/f/d)
-65% EG 13 TV-AVH-
hemozoin formation and digestive vacuole physiology in human malaria parasites.
Description of the project:
Malaria is a mosquito-borne disease that puts half of the world's population at risk of infection. It is caused by unicellular Plasmodium parasites, which repeatedly invade and lyse red blood cells in the human bloodstream. Throughout its development within the erythrocyte, the parasite ingests ~80% of the host cell cytoplasm, which is then catabolized in an acidic digestive vacuole. Proteolytic cleavage of hemoglobin releases the co-factor heme, which is highly toxic in its unbound form. To avoid cell damage, the parasite sequesters the host-derived heme into bioinert crystals known as hemozoin, which accumulate in the digestive vacuole. The transition from hemoglobin to hemozoin is essential for parasite survival and is exploited in antimalarial chemotherapy. In our group, we study the physiology and molecular machinery of the parasite's digestive vacuole as well as other parasite adaptations that are essential for blood stage survival.
The PhD project focuses on the identification and characterization of proteins and physicochemical factors that promote hemozoin formation in the human malaria parasite Plasmodium falciparum. In close interaction with other malaria research groups, the successful candidate will receive a comprehensive training in molecular and cell biology, ranging from the generation of transgenic cell lines (Cas9, DiCre, etc…) to the application of various state-of-the-art imaging techniques, such as live fluorescence microscopy, time-lapse microscopy, polarization microscopy and electron microscopy.
Matz JM. Plasmodium 's bottomless pit: properties and functions of the malaria parasite's digestive vacuole. Trends Parasitol. 2022; S1471-4922(22)00040-X
Matz JM, Drepper B, Blum TB, van Genderen E, Burrell A, Martin P, Stach T, Collinson L, Abrahams JP, Matuschewski K, Blackman MJ. A lipocalin mediates unidirectional heme biomineralization in malaria parasites. PNAS . 2020; 117:16546–56.
Starting date will be as soon as possible. The position is initially limited to 3½ years and according to the rules of the public service under the TV-AVH (collective agreement of the “Arbeitsrechtliche Vereinigung Hamburg“).
We support our employees in achieving a healthy work-life balance and promote the professional equality of women and men. We strive to assist women in their scientific career, increase the number of women in research and reduce under- representation in all areas and positions in general. We explicitly welcome applications from people with disabilities.
As a member of the Diversity Charter , the largest diversity management network in Germany, we are also committed to making diversity an integral part of our institute culture. It is our goal to create a working environment that is free of prejudice.
Please apply by 20.02.2023 preferably via our online form. with a motivation letter, CV, high school and university certificates and the names and contact information of two references.
Alternatively, you can submit your application referring to "PhDCellular Parasitology" via postal mail to: Bernhard Nocht Institute for Tropical Medicine, Ms. Katja Bünger, HR Department, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany.