The Rehabilitation Sciences of Hasselt University seeks a (m/f/x)
PhD student in Rehabilitation Sciences - Exercise physiology in metabolic
diseases: role of extracellular vesicles
Within the context of the expansion of the research of the REVAL
Rehabilitation Research group of Hasselt University the faculty of
Rehabilitation sciences wishes to inform about a vacant PhD position (100%)
in rehabilitation of internal diseases concerning the role of extracellular
vesicles in metabolic diseases (obesity and/or type 2 diabetes).
You will be part of the Faculty of Rehabilitation Sciences at UHasselt. This
faculty organizes an educational program consisting of a 3-year academic
bachelor and a 2-year academic master program within Rehabilitation Sciences
and Kinesitherapy. This program has approximately 850 students. The faculty
also provides education in the inter-university Master's in Occupational
Therapy Sciences. Within the faculty, REVAL ACADEMY organizes
interdisciplinary continuing education courses aimed at professionals in
healthcare and rehabilitation. The proposed research will be conducted within
the rehabilitation research group REVAL. REVAL is an interdisciplinary and
translational research group which performs research in the domains of
pediatric, neurologic and musculoskeletal rehabilitation, biomechanics, health
psychology, mental health care and rehabilitation of internal diseases. Within
the perspective of a "civic university" the RELAB platform facilitates the
provision of evidence based advice to individuals with a functioning problem
and professionals within the healthcare sector as well as to companies. This
PhD is done in collaboration with (inter)national rehabilitation centers.
In the field of exercise physiology in individuals with obesity, evidence is
accumulating that fat mass loss as a result of exercise training is small,
contributing to ineffective maintenance of long-term body weight goals.
Besides various clinical reasons, (patho)physiological abnormalities,
whether or not occurring during an acute exercise bout, may significantly
limit fat mass loss in weight loss trajectories. The mechanisms contributing
to these disappointing health benefits are incompletely understood. Gaining
new insights in the complex exercise-induced responses at the level of the
adipose tissue, as well as its contribution in inter-organ crosstalk will be
important to further unravel the pathophysiological exercise responses often
observed in individuals with metabolic diseases. In physiologic research,
extracellular vesicles (EVs) recently gained a lot of attention. EVs are
tiny particles produced by both healthy and unhealthy cells, serving as a
messenger between different cells or organs. These vesicles (by their
DNA/RNA, proteins, lipids) may alter their target cells' metabolism. Despite
the field is still in its infancy, fat tissue derived EVs are known to be
elevated in the circulation in individuals with obesity. However, there is
limited evidence available about the fat cell derived EVs and their changes
upon acute exercise or following long-term exercise training or other weight
loss interventions in individuals with obesity. Such studies will be important
for confirming the influence of weight loss interventions, with a great focus
on exercise interventions, on EVs parameters and to study their biological
content with established adaptations following exercise training in
metabolically comprised individuals like individuals with obesity. In this
project, we will further broaden the knowledge about fat tissue derived EVs in
individuals with obesity by using a translational approach, including both
fundamental and clinical research. You will follow the rules and guidelines of
the ‘doctoral school' of Hasselt University.
You have a Master in Rehabilitation Sciences, biomedical sciences, human
movement sciences (or equivalent)
Final-year students are (likewise) encouraged to apply.
You obtained good academic results.
You have a strong affinity with internal disease pathology and/or research
related to rehabilitation in internal diseases.
Experience with the target population (metabolic pathologies) or
intended research methodology is a plus.
You have knowledge on the design, execution and analysis of experimental
You have strong problem-solving skills, flexibility, organisational
capacity and stress resistance.
You have excellent communication skills in English (and Dutch), both
oral and written. If you do not know Dutch, you show the willingness to
study and speak Dutch within the PhD position.
You actively contribute to a positive working atmosphere, and make
connections between different (interdisciplinary) domains and people
(teaching assistants, PhD students, post-doctoral fellows, professors).
You will be appointed and paid as PhD student.
Position for 2 years. After positive evaluation one time extendable with 2
years. Positon at Hasselt University.
You can only apply online up to and including 23 June 2021.
The selection procedure consists of a preselection based on application file
and an interview.
A presentation or assignment is a possibility. The interviews are scheduled
for the first half of July 2021.
dr. Kenneth VERBOVEN, +32-11-269315, firstname.lastname@example.org
Prof. dr. Dominique HANSEN, +32-11-292126, email@example.com
More about working at Hasselt University? Check www. uhasselt.be/vacancies for
our staff benefits.