Created on January 1, 2011, the Interdisciplinary Institute of Neuroscience
(IINS) is a joint research unit attached to the CNRS and the University of
With 160 people in 14 teams, IINS combines multidisciplinary skills to study
the molecular and cellular mechanisms involved in brain activity. The
Institute develops innovative methods in imaging, chemistry, physiology and
computer science. As a component of Bordeaux Neurocampus, IINS is one of the
major actors of the neuroscience community in Aquitaine.
The objective of this thesis project is to use our technological lead in
imaging coupled with electrophysiology to revisit LTD. In particular, we will
redefine the respective changes in the organization and dynamics of AMPARs in
synaptic transmission during the early and sustained phases of LTD. This will
pave the way for new approaches to control LTD. In parallel, we will describe
the structural plasticity induced by LTD. We will then determine the molecular
link between these two plasticities.
- Use our super-resolution imaging techniques in living and fixed tissues to
characterize the organization and dynamics of AMPARs at the nanoscale;
- Combine calcium imaging to highlight active synapses with super-resolution
imaging and electrophysiology to correlate the content of synaptic AMPARs with
the strength of the associated synaptic response;
- Utilize a recently characterized molecular tool that allows the
immobilization of AMPARs both in brain slices and in vivo;
- Develop a long-term fluorescence imaging technique to monitor structural
plasticity in both cell culture and brain slices.
Research Field: Biological sciences Neurosciences
Location: France › PARIS 15
Main tasks: Surgical preparations and viral injections Two-photon imaging Data
connections in vigilant animals during multiphoton calcium imaging.
100% work in the team of Brice...
Oldenburg, Germany, offers a position of a
Our group is seeking a talented and highly motivated doctoral student (PhD
candidate) eager to work on a technically challenging neuroscience project
electrophysiology and imaging methods in vivo...
The Max Planck Institute for Biological Cybernetics in Tübingen (Germany)
invites applications from outstanding scientists for the position of Max
Planck Research Group Leader (W2) (m/f/d) in high-field MR human brain
The Max Planck Institute...
Research Field: Mathematics › Mathematical analysis Neurosciences
Location: Czech Republic › Prague
Institute of Physiology of the Czech Academy of Sciences (Prague, Czech
The Laboratory of Computational Neuroscience, Institute of Physiology, Academy
of Sciences of...