Research Field: Biological sciences › Biology
Researcher Profile: First Stage Researcher (R1)
Application Deadline: 05/10/2022 23:59 - Europe/Brussels
Location: France › MARSEILLE 09
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 01/01/2023
IBDM is located on the Luminy Campus and comprises about 240 permanent
researchers, professors, engineers and technicians and non-permanent staff
(CDD, post-docs, PhD students, trainees) distributed over 21 research teams
and 11 technical platforms and services.
IBDM is a joint research unit under the supervision of the CNRS and AMU, which
explores the field of developmental biology and associated pathologies.
The activity will be carried out within the team " Host pathogen interaction
in the Drosophila model" directed by Julien ROYET
As the team is composed of several nationalities, the practice of the English
language is essential.
Our body hosts billions of bacteria that colonize our skin our lungs and our
gut. The beneficial effect of some of these microorganisms on the development
and functioning of these bodies part has been well documented. Recent studies
show that by acting on the nervous system, gut bacteria also called
microbiota, can also change the behavior of infected individuals (4).
However, the underlying cellular and molecular mechanisms remain mostly
unknown. The laboratory of Julien Royet uses the Drosophila model to dissect
the molecular dialog between the microbiota and the nervous system of the
host. We have recently shown that infected flies have an altered behavior and
demonstrated that bacterial peptidoglycan is changing the comportment of
infected Drosophila by modulating NF-kB signaling in octopaminergic neurons
(1,2,5). Using Drosophila genetics, CRISPR-mediated genome editing and
latest imaging technologies, the recruited student will perform experiments to
understand how bacteria modulates the activity of neurons and how this
modulation translates into behavioural changes. Given the remarkable
evolutionary conservation in host defense and neuronal mechanisms, we believe
that the results obtained should be of significant relevance to an in-depth
understanding of bacteria-neurons interactions in organisms other than
Drosophila and namely in mammals in which such analyses are difficult to
Recent publications of the host lab:
1. Kurz CL, et. al. Peptidoglycan sensing by octopaminergic neurons modulates
Drosophila oviposition. Elife. 2017 Mar 7;6. pii: e21937.
2. Charroux B, et al. Cytosolic and Secreted Peptidoglycan-Degrading Enzymes
in Drosophila Respectively Control Local and Systemic Immune Responses to
Microbiota. Cell Host Microbe. 2018 Feb 14;23(2):215-228.e4.
3. Masuzzo A, et al, Peptidoglycan-dependent NF-κB activation in a small
subset of brain octopaminergic neurons controls female oviposition. Elife.
2019 Oct 29;8:e50559. doi: 10.7554/eLife.50559.
4. Masuzzo A, Montanari M, Kurz L, Royet J. How Bacteria Impact Host Nervous
System and Behaviors: Lessons from Flies and Worms. Trends Neurosci. 2020
5. Charroux B, Daian F, Royet J. Drosophila Aversive Behavior toward Erwinia
carotovora carotovora Is Mediated by Bitter Neurons and Leukokinin. iScience.
2020 Jun 26;23(6):101152. doi: 10.1016/j.isci.2020.101152.
6. Martina M and J Royet. Impact of Microorganisms and Parasites on
Neuronally Controlled Drosophila Behaviours Cells 2021, 10(9), 2350;
https: // doi.org/10.3390/cells10092350
Web site for additional job details
https: // emploi.cnrs.fr/Offres/Doctorant/UMR7288-CHRESS-042/Default.aspx
Required Research Experiences
YEARS OF RESEARCH EXPERIENCE
Biological sciences › Biology
YEARS OF RESEARCH EXPERIENCE
REQUIRED EDUCATION LEVEL
Biological sciences: Master Degree or equivalent
Department: Institut de Biologie du Développement de Marseille
Organisation Type: Public Research Institution
Website: https:// www. ibdm.univ-mrs.fr
City: MARSEILLE 09