This thesis is funded by the ANR NeGA project "Influence of effective
population size (Ne) on animal genome architecture" coordinated by Tristan
Lefébure of the LEHNA laboratory and in collaboration with the LBBE laboratory
in Lyon and the ISEM laboratory in Montpellier. The direction of this thesis
will be carried by Annabelle Haudry (scientific coordinator of the project
for LBBE and specialist of the biological model Drosophila), Anna-Sophie
Fiston-Lavier (member of ISEM and specialist of TEs) and Benoit Nabholz
(scientific coordinator of the project for ISEM and specialist of the
biological model birds). The PhD student, based in Montpellier, will interact
with all the partners of the project, and will travel regularly to Lyon.
- Main mission :
The main goal of the phD project will be to evaluate the influence of Ne (and
other relevant parameters such as the recombination and indel rates) on the
evolution of genome size and proportion of non-coding DNA as well as the
associated dynamics of TE.
- Activities :
Generate genomic resources for these groups : genome assembly combining
Minion long-reads (long but costly and error-prone) and Illumina short-
reads (short by cheap and accurate) technologies.
Transposable element (TE) annotation for the reference genomes
Estimation of polymorphism pattern of SNP and TE
Assessment of the impact of TEs on genome size
Effective population size (Ne) estimation
Assessing the fitness of TE dynamics using polymorphism data
Historical Ne reconstruction based on interspecific divergence/rate of
evolution using a Bayesian method developed by a member of the project
Student in PhD
Send you CV and your cover letter to Banoît NABHOLZ to his email box :
The candidate should have a background in evolutionary biology, particularly
in population genetics. An interest in bioinformatics
(programming, sequencing data analysis) is expected. A good knowledge in
statistics is also necessary.
We invite applications for a postdoctoral fellow at the University of
Copenhagen, as part of the COREX synergy project.
the top level of European Research Council funding, with a budget of €10
and Karl Göran-Sjögren),...