Phd Student In Biology (M/F)

Universities and Institutes of France

France

September 24, 2022

Description

  • Organisation/Company: CNRS
  • Research Field: Biological sciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 24/09/2022 23:59 - Europe/Brussels
  • Location: France › MONTPELLIER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/12/2022
  • We previously reported that colon carcinogenesis, in both mice and human, is associated with a decreased number of PC on colonic fibroblasts (Rocha et al. EMBP J, 2014). The PhD project we offer will explore the biomedical potential of PC and associated pathways in CRC. For this, the student will use tissue specific knock out mice, relevant animal models for CRC, immunohistochemistry, organoid cell cultures, biochemistry and RNAseq. Moreover, we collaborate with the local University Hospital as well as different clinical centers in Europe for the analysis of patient biopsies. Our recent publications illustrate our experimental strategy (Guo et al. J. Clin Invest, 2021; Maurizy et al. bioRxiv 10.1101/2019.12.19.882712, now in press at Nat Commun).

    Colorectal cancer (CRC) is the third most common and deadly cancer worldwide. CRC is a molecularly highly heterogeneous disease and there is an urgent need to map the heterogeneity of CRC, to identify novel therapeutic intervention points as well as prognostic and predictive biomarkers. Crucial in the regulation of intestinal homeostasis and pathology is the crosstalk between epithelium lining the crypts and neighbouring fibroblasts. An underexplored trait in cellular crosstalk are primary cilia (PC), an antennae‐like structure extruding the surface of many mammalian cells. PC serve as sensors of environmental signals and regulate a range of signalling pathways associated with carcinogenesis.

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/Doctorant/UMR5535-SARADE-017/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut de génétique moléculaire de Montpellier
  • Organisation Type: Public Research Institution
  • Website: https:// www. igmm.cnrs.fr/
  • Country: France
  • City: MONTPELLIER
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