PhD Student (f/m/d) – Crosstalk of the ubiquitin system with other post-
Job Code: 26-21
Job Offer from October 07, 2021
The Max Planck Institutes for Biophysical Chemistry and Experimental Medicine
in Göttingen are internationally leading research institutes of exceptional
scientific breadth, which will merge in 2022 to become the largest institute
of the Max Planck Society. The new institute will comprise more than 40
research groups and employ around 1,000 people from over 50 nations.
The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz)
invites applications for a position as
PhD student (f/m/d)
– Crosstalk of the ubiquitin system with other post-translational
Our lab aims to understand how ubiquitin − a single, small protein − achieves
specificity in regulating countless eukaryotic signaling pathways. A major key
lies in the precisely regulated action of the ubiquitin machinery, a catalytic
cascade of three classes of enzymes. These enzymes can provide powerful
therapeutic targets, as illustrated by the clinical efficacy of thalidomide
and derivatives in the treatment of hematologic malignancies. However, a
rational manipulation of ubiquitination enzymes for therapeutic benefit has
been limited by our insufficient understanding of their structural mechanisms
and regulation. To fill this gap, our lab combines chemical-biological,
biochemical, cell biological, and structural approaches (including NMR, X-ray
crystallography, and cryo-electron microscopy).
We are offering a fully-funded PhD position to explore the intriguing
question of how ubiquitination enzymes are regulated by other types of
posttranslational modifications, such as phosphorylation or redox-dependent
The successful candidate will have the opportunity to join one of several
attractive PhD programs within the Göttingen Graduate Center for
Neurosciences, Biophysics, and Molecular Biosciences, a collaboration with the
University of Göttingen (https: // www. uni-goettingen.de/en/56640.html).
Masters students aiming at a fast track PhD are also welcome to apply.
You have a Masters or equivalent degree in the life sciences, e.g.,
biology, biochemistry, biomedicine, biophysics, or chemistry.
You have a strong background in at least one of the following areas:
protein biochemistry, cell biology, or structural biology.
Initial expertise in human cell culture techniques would be beneficial.
You are keen to understand the structure and function of key enzymes by
working at the interface of biochemistry, cell biology, and structural
You are passionate about science, curiosity-driven, and highly self-
You are open-minded and enjoy being part of an international,
Based at one of Germany's premier research campuses, our independent research
group has access to leading-edge infrastructure in all fields of cell and
structural biology. We are an ambitious, international team, funded by the Max
Planck Society, the German Research Foundation, and the EMBO YIP. Our working
language is English; knowledge of German is not required. The historic city of
Göttingen, located in the center of Germany, offers great outdoor and cultural
opportunities, a vibrant student scene, and an impressive scientific heritage.
The position should be filled as soon as possible; the exact start date is
flexible. Payment and benefits are based on the TVöD guidelines.
Applications will be reviewed immediately until the position is filled.
Informal inquiries are also welcome.
The Max Planck Society is committed to increasing the number of individuals
with disabilities in its workforce and therefore encourages applications from
such qualified individuals. The Max Planck Society strives for gender and
diversity equality. We welcome applications from all backgrounds.
Please submit your application including cover letter (explaining background
and motivation), CV, transcripts, list of publications, and the contact
details of at least two academic referees by e-mail as a single PDF file to
Max Planck Institute for Biophysical Chemistry
Research Group “Ubiquitin Signaling Specificity”
Dr. Sonja Lorenz
Am Faßberg 11