Advertising division: ER-C-3 - Structural Biology
Reference number: 2021D-097
The Ernst Ruska Centre for Microscopy and Spectroscopy with Electrons (ER-C)
at Forschungszentrum Jülich is one of the world-leading electron microscopy
centres with more than 15 electron microscopes. The Structural Biology
division of the ER-C investigates the structural and molecular mechanism of
membrane biology and pushes the development of cryo-EM related methodology. At
the ER-C-3 ( https:// www. fz-juelich.de/er-c/er-c-3 ), we use a comprehensive
electron microscopy approach to study the biological structures of membrane-
associated protein complexes. Our main methods of investigation are single-
particle electron cryo-microscopy (cryo-EM) as well electron cryo-tomography
(cryo-ET) that we are also developing to advance existing imaging
technologies towards high-resolution structural biology.
We are offering a
PhD Position - Cryo-EM Image Analysis of Sars-CoV-2 Virus-Host Membrane
As a PhD student you will work on cryo-EM studies of virus-host membrane
interactions at the ER-C-3 in the field of Structural Biology at
Forschungszentrum Jülich with a particular focus on advanced image data
analysis methods. The ongoing COVID-19 pandemic caused by SARS-CoV-2 has major
global impact on human society, economy and daily life. The pathogenesis of
SARS-CoV-2 infection remains unclear, but most likely results from both a
direct cytopathic effect of the virus and a pathogenic inflammation-dominated
immune response. To gain knowledge about the virological and immunological
drivers of COVID-19 pathogenesis and the parameters of immune protection, we
united experts from 7 Helmholtz Centers in 4 Helmholtz Research Fields
(Health, Environment, Information and Aeronautics, Space & Transport) and 3
university partners across Germany, to create an internationally visible and
interdisciplinary network called CoViPa, in which the successful candidates
will be embedded. Your tasks include:
Work on high-resolution cryo-EM structure determination of in situ
cellular samples using correlative light and electron microscopy
Use and develop cryo-EM image processing methods to determine the 3D
structures of biological macromolecules in cells.
Employ novel imaging approaches and apply computational methods of pattern
recognition, artificial intelligence and deep learning to improve in situ
3D reconstruction, segmentation and molecular map interpretation methods.
Master`s degree in (bio)informatics, (bio)physics or related field.
Strong skills in scientific data analysis using mathematical script
Familiarity with the Unix operating system is required.
Prior knowledge in programming will be a plus and experience in open-
source software development is of great advantage.
Knowledge of machine learning methods will be beneficial.
Strong communication skills in English and ability to work in an
international and interdisciplinary team.
We work on the very latest issues that impact our society and are offering you
the chance to actively help in shaping the change! We offer ideal conditions
for you to complete your doctoral degree:
The Chance to work at one of the largest research centers in Germany, with
excellent scientific equipment and leading European computational
resources, located on a green campus, and near the cultural centers Köln,
Düsseldorf, and Aachen. The Jülich campus also hosts a vibrant biophysics,
bioinformatics and structural biology community.
Direct access to high-level cryo-EM infrastructure at the Ernst-Ruska
Centre. The facility has been extended with state-of-the-art cryo-
microscopes and FIB-SEMs of ThermoFisher Titan Krios, Talos Arctica and
Access to outstanding wet-lab laboratories at the host institute and to
the partner laboratories of the CoViPa consortium.
Working in a dynamic team of researchers with backgrounds in different
disciplines across biology, chemistry, physics and informatics to advance
A large research campus with green spaces, offering the best possible
means for networking with colleagues and pursuing sports alongside work
Further development of your personal strengths, e.g. through an extensive
range of training courses; a structured program of continuing education
and networking opportunities specifically for doctoral researchers via
JuDocS, the Jülich Center for Doctoral Researchers and Supervisors:
https: // www. fz-juelich.de/judocs
Targeted services for international employees, e.g. through our
International Advisory Service
The position is initially for a fixed term of 3 years. Pay in line with 75% of
pay group 13 of the Collective Agreement for the Public Service (TVöD-Bund)
and additionally 60 % of a monthly salary as special payment („Christmas
bonus“). Further information on doctoral degrees at Forschungszentrum Jülich
including our other locations is available at: https: // www. fz-
Forschungszentrum Jülich promotes equal opportunities and diversity in its
We also welcome applications from disabled persons.