Phd In Protein Chemistry Applied To Antibodies

Universities and Institutes of Italy

Italy

June 20, 2021

Description

  • Organisation/Company: University of Campania Luigi Vanvitelli
  • Research Field: Chemistry › Biochemistry
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 30/06/2021 12:00 - Europe/Athens
  • Location: Italy › Napoli
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/11/2021
  • The PhD program in Biomolecular Sciences is a research doctorate of the University of Campania Luigi Vanvitelli in Caserta-Naples, Italy. The program is multidisciplinary and based on a well-balanced combination of research activity with access to the most modern technological platforms, theoretical courses, internal seminars and participation to national and international conferences. The official language of the Doctorate program is English. Research and training activities will take place in the Department of Environmental, Biological and Pharmaceutical Sciences and Technologies of the University of Campania Luigi Vanvitelli, via Vivaldi, Caserta and in the CNR Institutes of Genetics and Biophysics A. Buzzati-Traverso, Institute of Biochemistry and Cell Biology, and Biostructures and Bioimagingof Napoli. All these institutions provide an international and very stimulating research environment for the students. The students will spend part of their doctorate (at least 3 months) in research groups abroad.

    Your project: Cancer therapies based on the selective activation of T cells targeting highly specific Tumor Associated Antigens (TAAs) are a new successful option in the fight against several malignancies. Forefront approaches are based on the use of dual specificity proteins, called T cell engagers (TCE), composed of bi-specific antibodies or antibody fragments (AF), that simultaneously target one epitope on T cells and a second epitope on specific TAAs on cancer cells. This novel class of biotherapeutics works by recruiting T cells on the surface of tumor tissues promoting their destruction. The project aims to develop new TCEs based on bispecific AFs which are assembled through consensus sequences reactive toward microbial transglutaminase (MTG). The bispecific AFs will be composed of an anti-CD3 scFv or Fab and an AF against known TAAs selectively expressed in tumors, including breast cancer, glioblastoma and colorectal cancers. The new molecules characterized at analytical and functional level are expected to open new perspectives for treating refractory solid cancers.

    Supervisor: Dr. Annamaria Sandomenico. Email: annamaria.sandomenico@cnr.it. Publications:Scopus Author ID: 23978865200; https: // orcid.org/0000-0001-5255-3668. Candidatesshould contact the supervisor to arrange a preliminary interview by Skype as soon as possible.

    Your qualification: Master degree in chemistryor pharmaceutical chemistry or biology (and related fields) or equivalent obtained in countries other than Italy. Preference will be given to candidates with experience in protein chemistry and antibody development.

    Our offer: 3-year PhD student position with scholarship from Nov 1, 2021 to Oct 31st, 2024

    Evaluation Criteria

    - Curriculum assessment concerns:

    a) Master degree thesis (pertinence with Ph.D. topics, final grades);

    b) certified knowledge of Foreign languages;

    c) research and study abroad;

    d) scholarships;

    e) post graduate qualifications;

    f) publications, conference abstracts, reference letters.

    g) a written research project on the topics of the PhD program following the instructions reported in the call https: // www. unicampania.it/RipartizioniFS/RAG/DottoratidiRicerca/37/BandoXXXVIIciclo- istituzione-concorso-schedeING.pdf

    - The oral testwill concern a discussion on the qualifications and the research project submitted and will be conducted electronically via Skype (or another similar tool).

    How to apply

    Contact the supervisor for a preliminary interview as soon as possible and then apply online by following the instructions reported in the callhttps: // www. unicampania.it/RipartizioniFS/RAG/DottoratidiRicerca/37/BandoXXXVIIciclo- istituzione-concorso-schedeING.pdf

    Benefits

    We offer a 3-year PhD position, available upon admission to the PhD program in Biomolecular Sciences of the University of Campania “Luigi Vanvitelli”. The winner of the position will receive a scholarship of 15,343.28 euro which will be prepaid every month. The amount of the scholarship will be increased by 50% for research visits outside of Italy.

    Eligibility criteria

    - Academic degree: master degree or equivalent corresponding to the second level of studies.

    - Mobility rule: Applicants can be from any Country, but should have received their degree from a University located outside of Italy.

    Selection process

    Candidates will be selected on the basis of an interview and will be next invited to apply to the recruitment call. In case of positive outcome of the recruitment, the position will be available starting in November 2021.

    The procedures for carrying out the admission tests

    - Evaluation of qualifications, including the compulsory submission of a research project according to the format indicated in art. 6;

    - Interview through Skype (or other similar tools);

    - Foreign language which will be verified during the interview: English.

    Location and calendar of the competition

    Consult the following web page of the Department, from July 10, 2021

    https: // www. distabif.unicampania.it/didattica/dottorato-di-ricerca-in-sc...

    Additional comments

    What we are looking for

    The ideal candidate has a Master degree in chemistryor pharmaceutical chemistry or biology (and related fields) and a background inprotein chemistry, monoclonal antibodies development.Expertise in molecular and/or cellular biology are also welcome. Willingnessto work with interdisciplinary approaches and communication and organizational skills are also appreciated. Finally, fluent spoken and written English language knowledge is required.

    How to apply

    Please send your pre-application as a single pdf in English. The application should include a cover letter (summarizing your experience, your future vision and your interest in the project), a CV of no more than 4 pages (and including the list of publications) and relevant certificates (degree certificates, etc.) to Dr. Annamaria Sandomenico. Email: annamaria.sandomenico@cnr.it.

    The deadline for submission is 20.06.2021

    Short listed candidates will be invited for an online Skype interview.

    For queries, email to annamaria.sandomenico@cnr.itand menotti.ruvo@unina.it

    Web site for additional job details

    https: // www. unicampania.it

    https: // www. distabif.unicampania.it/didattica/dottorato-di-ricerca-in- scienze...

    Required Research Experiences
  • RESEARCH FIELD
  • Chemistry › Biochemistry

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: Master Degree or equivalent

    Chemistry: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Excellent

    Skills/Qualifications

    The ideal candidate has a Master degree in chemistryor pharmaceutical chemistry or biology (and related fields) and a background in protein chemistry. Expertise in molecular and/or cellular biology are also welcome. Willingness to work with interdisciplinary approaches and communication and organizational skills are also appreciated. Finally, fluent spoken and written English language knowledge is required.

    Contact Information
  • Organisation/Company: University of Campania Luigi Vanvitelli
  • Department: DiSTABiF
  • Organisation Type: Higher Education Institute
  • Website: https: // www. distabif.unicampania.it/
  • E-Mail: annamaria.sandomenico@cnr.it menotti.ruvo@unina.it
  • Country: Italy
  • City: Caserta
  • Postal Code: 81100
  • Street: Via Vivaldi 43
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