Phd In Molecular Biology (F/M)

Universities and Institutes of France
December 06, 2022
Contact:N/A
Offerd Salary:Negotiation
Location:N/A
Working address:N/A
Contract Type:Temporary
Working Time:Full time
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Job Ref.:N/A
  • Organisation/Company: CNRS
  • Research Field: Biological sciences Medical sciences Pharmacological sciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 06/12/2022 23:59 - Europe/Brussels
  • Location: France › MONTPELLIER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 23/01/2023
  • Eu Research Framework Programme: H2020 / ERC
  • The Institute of Molecular Genetics of Montpellier (IGMM) is a joint research unit of CNRS and the University of Montpellier, with 200 people divided into 17 research groups, 9 common services (5 of which are shared with other units of the CNRS campus) and 9 technological and scientific platforms. The IGMM is a multidisciplinary institute whose work has an international impact in molecular and cellular biology (www. igmm.cnrs.fr). The PhD student will be assigned to the new team, which was created within the IGMM a year ago and whose theme is "RNA viruses and host factors", directed by Karim MAJZOUB.

    The thesis subject focuses on the study of restriction factors opposing the replication of Hepatitis Delta virus (HDV) and the Deltavirus family in general. A genetic screen focused on ISGs (Interferon Stimulated Genes) family will be performed to identify genes that would negatively regulate viral genome expression. The contribution of the identified candidates in Deltavirus replication will then be studied by gene depletion and overexpression methods (cDNA, CRISPR), microscopy (smFISH, Immunofluorescence), Western blot, qPCR and Northern blot. These techniques will be performed in several animal cell lines (human, rodent, snake) as well as in a mouse animal model. The aim of the project is to identify and characterize ISGs suspected of inhibiting Deltavirus replication. This work will provide important fundamental knowledge regarding animal immunity to the Deltavirus family. Moreover, this knowledge could lead to new applied antiviral strategies to fight against this family of viruses, against which there are no effective antivirals to date.

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/Doctorant/UMR5535-SARADE-025/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Medical sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Pharmacological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: Master Degree or equivalent

    Medical sciences: Master Degree or equivalent

    Pharmacological sciences: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut de génétique moléculaire de Montpellier
  • Organisation Type: Public Research Institution
  • Website: https:// www. igmm.cnrs.fr/
  • Country: France
  • City: MONTPELLIER
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