Phd In Medicinal Chemistry. Fluorinated Foldamers: Synthesis, Structuration And Capacity To...

Universities and Institutes of France

France

October 20, 2022

Description

  • Organisation/Company: Université Paris-Saclay
  • Research Field: Chemistry › Organic chemistry
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 20/10/2022 21:00 - Europe/Athens
  • Location: France › Orsay
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/01/2023
  • Eu Research Framework Programme: H2020 / Marie Skłodowska-Curie Actions
  • Marie Curie Grant Agreement Number: 860070
  • Peptides capable of mimicking the secondary structures of proteins are very promising candidate molecules to modulate protein-protein and protein-membrane interactions. However, their use in therapy remains very limited due to their low resistance to proteolysis. Peptidomimetic foldamers are a class of compounds capable of adopting well-defined secondary structures with the advantage of being very stable against proteases. At the same time, the use of fluorinated compounds in medicinal chemistry has become widely popular, with the incorporation of fluorine atoms being of major interest to modulate their physicochemical and therapeutic properties. Although the combination of fluorine and foldamers appears to be an innovative strategy for the development of new drugs, fluorinated foldamers remain to date unexplored compounds in medicinal chemistry. In this three years PhD project, we will design, synthesize and study the introduction of specific fluorinated motifs into foldamers mimicking α/310 helix and beta-hairpins, and explore their ability to interact with amyloid proteins to inhibit their aggregation, as well as to cross biomembranes as cell-penetrating peptides.

    Selection process

    To apply: please send a detailed CV, a letter of motivation and your M1 and M2 scores to sandrine.ongeri@universite-paris-saclay.fr

    A letter of recommendation from your two M1 and M2 internship supervisors must be sent by e-mail also directly by your supervisors to Prof. Sandrine Ongeri.

    After selection from the CV, some interviews with selected candidates will be organized.

    Offer Requirements Skills/Qualifications

    Holder of Master 2 degree (or international equivalent), the candidate must have a good theoretical and practical knowledge of organic synthesis as well as of the methods of analysis and characterization of organic compounds. A first experience in peptide chemistry and good knowledge in NMR conformational analyses could be a plus.

    Specific Requirements

    To apply: please send a detailed CV, a letter of motivation and your M1 and M2 scores to sandrine.ongeri@universite-paris-saclay.fr

    A letter of recommendation from your two M1 and M2 internship supervisors must be sent by e-mail also directly by your supervisors to Prof. Sandrine Ongeri.

    Contact Information
  • Organisation/Company: Université Paris-Saclay
  • Department: BioCIS
  • Organisation Type: Public Research Institution
  • Website: https: // www. universite-paris-saclay.fr/en
  • E-Mail: sandrine.ongeri@universite-paris-saclay.fr
  • Country: France
  • City: Orsay
  • State/Province: France
  • Postal Code: 91400
  • Street: Bat. Henri Moissan, 17 av. des Sciences
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