PhD in Ice-Binding protein polymers
Are you fascinated by ice-binding proteins? Are you interested in (computer-
aided) protein engineering, ice crystal growth, and biomineralization? Are
you passionate about your research? Do you want to work in a multidisciplinary
Chemical Engineering and Chemistry
A remarkable class of biopolymers known as ice-binding proteins alleviate the
risk of freeze injury throughout the Kingdoms of Life by keeping the
nucleation and growth of ice crystals in check. Yet, the application potential
of analogues of ice-binding proteins as cryoprotectants has remained
underexploited. This is because we are yet to unravel and utilize the
structure-function relations, which govern their activity as inhibitors of ice
recrystallization and promoters of ice nucleation at the single-molecule level
in vitro and within a complex biological environment. In this project you will
design and synthesize and study new ice-binding protein-polymers, with the aim
to modulate independently their ability to inhibit recrystallization, control
nucleation, and shape ice crystals at submicromolar concentrations. You will
develop efficient synthesis and purification strategies suitable for upscaling
to fabricate these powerful materials at large scale and relatively low cost.
You will obtain the ice-binding protein-polymers as recombinant proteins
encoded by synthetic genes that are designed and constructed by yourself. You
will establish structure-activity relations to customize activity and – in
collaboration with other group members – investigate their ice-binding at the
single molecule level as well as their application potential in biomedicine.
A master's degree (or an equivalent university degree) in Molecular
Biology, Biomedical Technology, Molecular (Life) Sciences,
Bionanotechnology, Molecular Biophysics, or related discipline.
A research and goal-oriented attitude.
A solid background in molecular biology, preferably with experience in
fermentation / bioprocess technology, and with a clear affinity for
(computer-aided) protein engineering, biophysics, and/or soft matter
Experience with microscopy (optical/fluorescence/cryo-TEM/AFM),
crystallization and microfluidics is preferred.
Ability to work independently and enthusiastic about working in a dynamic,
interdisciplinary, and international context.
Fluent in spoken and written English. Good communication skills.
Conditions of employment
A meaningful job in a dynamic and ambitious university with the
possibility to present your work at international conferences.
A full-time employment for four years, with an intermediate evaluation
after one year.
To support you during your PhD and to prepare you for the rest of your
career, you will have free access to a personal development program for
PhD students (PROOF program).
A gross monthly salary and benefits in accordance with the Collective
Labor Agreement for Dutch Universities.
Additionally, an annual holiday allowance of 8% of the yearly salary, plus
a year-end allowance of 8.3% of the annual salary.
A broad package of fringe benefits, including an excellent technical
infrastructure, moving expenses, and savings schemes.
Family-friendly initiatives are in place, such as an international spouse
program, and excellent on-campus children day care and sports facilities.
Information and application
For further information on this vacancy please contact
Prof. Dr. Ir. Ilja Voets, i.voetsattue.nl or +31 40 247 5303
For information about terms of employment, please contact Leo van Houten,
l.v.houtenattue.nl or +31 40 247 8269
Please visit www. tue.nl/jobs to find out more about working at TU/e!
We invite you to submit a complete application by using the 'apply now'-button
on this page. The application should include a:
Cover letter in which you describe your motivation and qualifications for the
Curriculum vitae, with information on education, employment, and research
experience including a list of your publications and the contact information
of three references.
A letter of recommendation from one or more of your references
A copy of your MSc graduation thesis or internship report.
We do not respond to applications that are sent to us in a different way.
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necessary, please combine files.
We look forward to your application and will screen it as soon as we have
received it. Screening will continue until the position has been filled.