Phd In Computational Chemistry/Biology

Universities and Institutes of France

France

October 10, 2021

Description

  • Organisation/Company: Université de Strasbourg
  • Research Field: Chemistry Medical sciences
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Leading Researcher (R4)
  • Application Deadline: 10/10/2021 00:00 - Europe/Brussels
  • Location: France › Illkirch-Graffenstaden
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • The PhD position is available in Esther Kellenberger's group in the chemoinformatics and medicinal chemistry laboratory. Esther Kellenberger's research focuses on the structural and dynamic basis of protein-ligand recognition, with the aim of discovering bioactive molecules or therapeutic substances. As part of multi-disciplinary projects with academic partnerships, a major research focus is the study of G protein coupled receptors (GPCRs) and their signaling pathways. GPCRs are membrane proteins which play key roles in many physiological processes. With more than hundred members being target for drugs approved in the United States or European Union, this protein family constitute an essential therapeutic class.

    The doctoral thesis is about the dimerization of two chemokine receptors which are involved in the immune cell trafficking and which have been implicated in the physiopathology of multiple diseases, including viral infections, metabolic diseases, neurodegeneration and progression of cancers. The thesis work will involve the in silico modeling of 3D structures, the development of predictive models and the search for functional modulators.

    Funding category: Financement public/privé

    ANR

    PHD title: Doctorant de Chimie informatique et théorique

    PHD Country: France

    Offer Requirements Specific Requirements

    Applicants should have a strong background in structural bioinformatics, computational chemistry, chemoinformatics, or a related discipline.

    The expected skills are a good knowledge in protein structure and molecular recognition, and hands-on experience with visualization of biomolecule, programming/scripting and numerical calculations. During the thesis, the doctoral student will be expected to handle the following concepts and master the techniques for their study or implementation: homology modeling, pharmacophore modeling, molecular docking, molecular dynamics simulation, virtual screening. Familiarity with Python scientific programming language is considered beneficial.

    We are looking for a proactive and motivated young scientist, having good interpersonal skills, strong team spirit, and capable of effective oral and written communication. He/she will show proficiency in English.

    Contact Information
  • Organisation/Company: Université de Strasbourg
  • Organisation Type: Large Company
  • Website: https: // medchem.unistra.fr/
  • Country: France