Phd - Development Of Peptide-Based Inhibitors Of Influenza Virus (H/F)

Universities and Institutes of France

France

September 29, 2021

Description

  • Organisation/Company: CNRS
  • Research Field: Biological sciences › Biological engineering Chemistry › Biochemistry Physics › Biophysics
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 29/09/2021 23:59 - Europe/Brussels
  • Location: France › GRENOBLE
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/01/2022
  • The PhD student will work in the Virus Replication Machines (VRM) group of the Institut de Biologie Structurale (IBS) in Grenoble, supervised by Darren Hart. The IBS (www. ibs.fr) is afilliated with the CNRS, the CEA and the UGA, and is located on the EPN Campus. This site is recognised globally for its research in structural biology with large instruments, notably the European Synchrotron Radiation Facility (ESRF), and a dozen smaller platforms providing all necessary tools for structural biology research e.g. biophysics, electron microscopy, NMR, mass spectrometry, protein crystallisation, etc. (www. isbg.fr). The project is funded for 3.5 years by the French National Research Agency (ANR) and involves consortium partners at the Institut Pasteur and the UGA with whom the student will interact. The student will participate and present project results at local and national events organised by local and national communities including the IBS, the Partnership for Structural Biology (PSB; www. psb-grenoble.eu), the UGA Chemistry & Life Sciences Doctoral School (EDCSV) and the RESAFLU network.

    The candidate must have a Masters in biology or biochemistry. The post requires sound knowledge of molecular biology and interests in areas such as virology, drug discovery, protein engineering and/or structural biology, plus a basic knowledge of bioinformatics. A high level of communication skills in English, both oral and written, is required to be able to present at conferences and write articles in scientific publications.

    Applications must include a detailed CV; at least two references (people who may be contacted); a cover letter of one page; a short summary of the dissertation for the Masters degree (or equivalent); grades for the Masters 1 and 2 or diploma.

    The thesis project aims to develop new peptide-based inhibitors of influenza virus through a combination of structural biology, protein engineering, cell biology and peptide chemistry. There is an important need for new antivirals as a complement to vaccination due to issues of viral resistance. Phage display directed evolution (see Nobel Prize in Chemistry 2018) will be used to generate high affinity peptide inhibitors of viral and host protein complexes that are essential for influenza virus replication. Hits will be characterised using biophysical methods and X-ray crystallography at the facilities of the EPN Campus in Grenoble, followed by cellular assays of virus replication in collaboration with the Institut Pasteur, Paris. Working with our peptide chemistry partner at the University of Grenoble Alpes (UGA), peptides will be improved by chemical modification to improve their properties of cellular import, target-binding and stability. Initial results have been obtained in our lab, indicating the feasibility and exciting potential of this approach.

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/Doctorant/UMR5075-JERGAU-013/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Chemistry › Biochemistry

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Physics › Biophysics

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Biological sciences › Biological engineering

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Chemistry: Master Degree or equivalent

    Physics: Master Degree or equivalent

    Biological sciences: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut de biologie structurale
  • Organisation Type: Public Research Institution
  • Website: https:// www. ibs.fr/
  • Country: France
  • City: GRENOBLE
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