Path 1: Research Assistant - Synthesis and Application of New Drug Delivery Systems based on Iron-oxide and Nobel metals Nanoparticles

New York University

United States

February 6, 2022

Description

Path 1: Research Assistant - Synthesis and Application of New Drug Delivery

Systems based on Iron-oxide and Nobel metals Nanoparticles

New York University: NYU - Global: Abu Dhabi Location

Abu Dhabi

Open Date

Nov 22, 2018

Description

RESEARCH PROJECT TITLE: SYNTHESIS AND APPLICATION OF NEW DRUG DELIVERY SYSTEMS BASED ON IRON-OXIDE AND NOBEL METALS NANOPARTICLES

FACULTY NAME & TITLE: ALI TRABOLSI, ASSISTANT PROFESSOR IN CHEMISTRY, MAZIN MAGZOUB, ASSISTANT PROFESSOR IN BIOLOGY

RESEARCH PROJECT DESCRIPTION:

The focus of the project is on the development of a novel therapeutic nanoplatform, Targeted Chemotherapeutic Nanoparticles (T-CNPs), for the diagnosis and treatment cancer. The T-CNPs will be composed of iron oxide NPs that are: i) functionalized with water-soluble organic nanocontainers, for the encapsulation of a combination of hydrophobic and/or hydrophilic drugs that can act synergistically; ii) conjugated to cell-penetrating peptides (CPPs) – either directly, or through encapsulation of the NPs within polyethylene glycol-modified liposomes (to avoid immune recognition) that are surface-coated with CPPs – which will enhance specific targeting of tumors and internalization into cancer cells. The aim is to use the nanoplatform to simultaneously target a tumor, monitor it by magnetic resonance imaging (MRI), and treat the disease by controlling the gradual release of the delivered anti-cancer drugs using a non-invasive external stimulus, which will concurrently induce hyperthermia. We will highlight new ways for the active release of the drugs, particularly by an external magnetic field, and promote the understanding of complex in vivo phenomenon when the molecules are optimally delivered.

RESPONSIBILITIES OF THE POSITION:

• Conduct research in the area of nanoparticles (synthesis, surface functionalization and characterization)

• Conduct experiments using host-guest chemistry

• Cell culture

• Conduct experiments in the field of drug delivery, including cell viability/toxicity assays and high-resolution imaging

Qualifications

ESSENTIAL QUALIFICATIONS:

• Bachelor of Science majoring in Chemistry/Biochemistry/Biology

• Experience in organic synthesis, general chemistry, or cell/molecular biology

• Excellent communication skills

PREFERRED EXPERIENCE / SKILLS:

In addition to the necessary knowledge of science and chemistry/biology, a research chemist/biologist must be curious about the natural world and the ability to come up and develop new experiments. He/she will be required to work and collaborate with other scientists within the group as well as from different fields. This ability to work in a team setting and communicate with others is very important. Lab research work experience is an asset.

Application Instructions

1. Statement of interest in the position

2. Transcript of degree(s)

3. CV

4. Two letters of recommendation

Application Process

This institution is using Interfolio's Faculty Search to conduct this search. Applicants to this position receive a free Dossier account and can send all application materials, including confidential letters of recommendation, free of charge.

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