Open PhD position to study membrane-mediated protein self-assemblyUniversity of Bonn • Life and Medical Sciences Institute • Bonn

Germany Universities

Germany

October 15, 2021

Description

Open Positions 2

Time Span as soon as possible for 3 years Application Deadline 15 Oct 2021 Financing yes Type of Position

  • PhD - Individual Supervisor
  • Field of Research

  • Mathematics / Natural Sciences
  • Subjects Molecular biology, protein biochemistry, physics, biophysics and/or computational biology Description The group of Protein Design and Self-Assembly at the Life and Medical Sciences Institute, University of Bonn is offering a PhD position (TV-L EG 13 50%) to study membrane-mediated protein self-assembly.

    The project

    The Khmelinskaia lab has a novel hybrid approach to study protein self- assembly: we combine de novo computational protein design and in vitro biophysical characterization to dissect the physical principles behind this ubiquitous phenomenon. In one of our projects, we aim to understand the fine balance between protein-protein and protein-membrane interactions, protein structural flexibility and membrane elasticity that allow for the formation of curvature inducing protein coats, involved in a number of important biological processes such as viral envelopment and endocytic signaling pathways. De novo designed proteins can not only recapitulate the self-assembling behavior of natural systems but are also more resilient to modification then their natural counterparts, while in vitro model systems allow us to investigate the process in a controlled environment. We use computational tools, such as Rosetta based protein design and structural predictions, to create protein scaffolds with precise properties and characterize their assembly pathways in vitro using structural biophysical methods, model lipid membranes and microcopy techniques. We aim to capture the behavior of naturally occurring systems and further map out the possible assembly space.

    The research project is adaptable to the candidates' interests.

    Your profile

    • Enthusiasm for research in a collaborative environment • Strong interest in solving fundamental biological problems • Experience in molecular biology, protein biochemistry, physics, biophysics and/or computational biology (Master's degree or equivalent) • Excellent degrees and track record • Very good communication skills (English)

    We offer

    • Challenging projects at the interface of biophysics, molecular biology and computational biology • A stimulating, multidisciplinary and international research environment • Supportive mentoring • Salary will be according to the German salary scale TV-L EG 13 • A “Jobticket” (subsidized public transport) is available • There is also a possibility to use the day care center • Supplementary benefits in the public sector (pension plan according to VBL) • numerous offers of university sports

    Contact information

    We welcome people from all backgrounds to join our lab! To apply, please send your CV, short motivation letter and contact information of 2 scientific referees to Alena Khmelinskaia via email (akhmelin@uni-bonn.de)

    Working Language

  • English
  • Language of Dissertation

  • English
  • Required Documents

  • CV
  • Letter of Motivation
  • Others : Contact details of two scientific referees
  • More Information https: // www. limes-institut- bonn.de/fileadmin/userupload/Group-Khmelinskaia/pdf/PhDposition.pdf

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