Organisation/Company: Foundation for Research and Technology-Hellas
Research Field: Computer science Neurosciences
Researcher Profile: First Stage Researcher (R1)
Application Deadline: 20/08/2021 00:00 - Europe/Athens
Location: Greece › AGIOS MYRONAS
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 40
Offer Starting Date: 01/10/2021
Eu Research Framework Programme: H2020
Reference Number: 863245
We are looking for one motivated postdoc to join the Laboratory of Dr.
Panayiota Poirazi at IMBB-FORTH.
The successful applicant will work on a multidisciplinary collaborative
project aiming to develop a new prototype technology that can be used for drug
discovery for neurological diseases. In this new hybrid technology,
computational neuronal networks that simulate dysfunction will drive cultured
neurons to replicate Alzheimer's disease. Nanoelectrodes will mediate the
transmission between simulated and biological neurons, at multiple subcellular
locations. Neuronal responses will be read out with advanced imaging
techniques and will be fed back to the simulated neurons, closing the loop and
enabling control of activity states across the hybrid population. A proof-of-
concept will be provided for Alzheimer's disease, using human (iPSC)-derived
neurons while testing the effects of novel drug candidates. The NEUREKA
partners include the University of Padua (Prof. Vassanelli), CNRS (Prof.
Larrieu), the University of Milano Bicocca (Prof. Fanciulli) and Maxwell
The successful candidate will work on the development of computational circuit
models of neurons equipped with dendritic nonlinearities and plasticity for
different brain areas (based on the model developed in the Poirazi Lab, by
Kastellakis et al, Cell Reports, 2016). He/She will also work with developing
and/or applying techniques for processing calcium imaging data (from behaving
animals and/or cultured neurons) and the interfacing of the model with
nanoelectrodes and neuronal outputs.
The Poirazi Lab investigates how dendrites and their integrative properties
contribute to learning and memory related functions, using primarily
computational techniques. In close collaboration with experimentalists, models
are used to explain findings and predict new roles for dendrites in functions
such as spatial navigation/learning, working and associative memory, visual
processing etc. The lab has recently expanded its research to include
experiments in mice, whereby the role of dendrites in prefrontal functions is
investigated via behavioral, electrophysiological and imaging techniques. The
laboratory offers a thriving, ambitious research environment which is well
funded from several grants.
Vacancy terms: Full Time, Fixed Term from 1st October 2021 for 1 year
Salary: Postdoc salary commensurate with experience: 26.000€ - 36.000€ per
annum (monthly cost)
Applications (full CV, statement of research interest and name and contact of
2-3 referees) should be sent by e-mail to firstname.lastname@example.org, quoting
“NEUREKA: PhD position (ORZ-0319)” in the subject line.
The deadline for applications is midnight, August 20th, 2021 (GMT+2).
Applications will be examined until the position is filled. Informal enquiries
IMBB (www. imbb.forth.gr) is part of FORTH (www. forth.gr), one of the
leading research foundations worldwide. IMBB is one of the most prominent life
science research institutions in Greece, with an outstanding record of
scientific achievements, state of the art infrastructure and a broad range of
research, innovation and high quality, inspirational educational activities.
In addition, IMBB is strongly committed to inclusivity, promoting equality and
celebrating diversity among its staff and students.
The wide-range of research activities in the Institute aim at understanding
the basic biological processes operating in living organisms. IMBB also hosts
interdisciplinary research programs at the interface of biology with
informatics, chemistry, physics or medicine and is heavily involved in
providing post-graduate students high-level education through joint graduate
programs with the University of Crete. An additional standing mandate of IMBB
is the exploitation and translation of acquired knowledge to tangible societal
benefits, including the development of new technologies, innovative products
IMBB is located close to Heraklion which is the largest city and the
administrative capital of the island of Crete, located south of the Greek
mainland. It is the fifth largest city in Greece with a population of >
140,000 and is famous for its lively lifestyle and the outstanding outdoors.
We seek candidates holding a PhD in Neuroscience and a keen interest in
Computational Neuroscience. They must be highly motivated and creative
individuals who want to work in a dynamic, multi-disciplinary research
environment and be willing to interact with both experimental and theoretical
neuroscientists. Previous experience should demonstrate the ability to work
independently (e.g. via designing and carrying out work with custom-built set
ups) and provide a multidisciplinary training (e.g. knowledge of techniques
beyond programming, such as advanced imaging of neuronal activity, ideally 2
photon calcium imaging, and behavioral assays). Experience or familiarity
with related computational skills, including use of specialized software
(ScanImage, ImageJ, IgorPro, Adobe Illustrator) and programming experience
(Python, Matlab) is desirable. Candidates will also have the opportunity to
become involved with computational modeling of neuronal circuits, which is
well established in our lab.
Characteristics of the ideal candidate:
PhD in Neuroscience, Neurophysiology or a related subject.
Experience in developing, using and troubleshooting custom-built set ups
(e.g. imaging and behavioral set ups)
Experience in advanced imaging techniques (2 photon calcium imaging and
Experience in behavioral assays
IT skills in specialized packages (ScanImage, ImageJ, IgorPro, Adobe
Illustrator) and programming experience (Python, Matlab)
Experience with analysis and processing of experimental data.
Experience in scientific writing/communication/presentations
delivery/publishing (proven by a corresponding list of publications).
Fluency in spoken and written English and Greek.
Strong communication and interpersonal skills, being able to work
comfortably both in a team and independently.
Ability to work with minimal supervision, prioritizing own workload to
deal with urgent tasks, while maintaining a high standard of accuracy and
attention to detail.
Willingness to travel.
Organisation/Company: Foundation for Research and Technology-Hellas
Department: Institute of Molecular Biology and Biotechnology
Organisation Type: Public Research Institution
Website: https:// www. imbb.forth.gr
Postal Code: 70013
Street: Vassilika Vouton