One (1) Postdoctoral Researcher Position [Ref # Orz-0318]

Universities and Institutes of Greece

Greece

August 20, 2021

Description

  • Organisation/Company: Foundation for Research and Technology-Hellas
  • Research Field: Computer science Neurosciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 20/08/2021 00:00 - Europe/Athens
  • Location: Greece › AGIOS MYRONAS
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/10/2021
  • Eu Research Framework Programme: H2020
  • Reference Number: 863245
  • We are looking for one motivated postdoc to join the Laboratory of Dr. Panayiota Poirazi at IMBB-FORTH.

    The successful applicant will work on a multidisciplinary collaborative project aiming to develop a new prototype technology that can be used for drug discovery for neurological diseases. In this new hybrid technology, computational neuronal networks that simulate dysfunction will drive cultured neurons to replicate Alzheimer's disease. Nanoelectrodes will mediate the transmission between simulated and biological neurons, at multiple subcellular locations. Neuronal responses will be read out with advanced imaging techniques and will be fed back to the simulated neurons, closing the loop and enabling control of activity states across the hybrid population. A proof-of- concept will be provided for Alzheimer's disease, using human (iPSC)-derived neurons while testing the effects of novel drug candidates. The NEUREKA partners include the University of Padua (Prof. Vassanelli), CNRS (Prof. Larrieu), the University of Milano Bicocca (Prof. Fanciulli) and Maxwell Biosystems.

    The successful candidate will work on the development of computational circuit models of neurons equipped with dendritic nonlinearities and plasticity for different brain areas (based on the model developed in the Poirazi Lab, by Kastellakis et al, Cell Reports, 2016). He/She will also work with developing and/or applying techniques for processing calcium imaging data (from behaving animals and/or cultured neurons) and the interfacing of the model with nanoelectrodes and neuronal outputs.

    The Poirazi Lab investigates how dendrites and their integrative properties contribute to learning and memory related functions, using primarily computational techniques. In close collaboration with experimentalists, models are used to explain findings and predict new roles for dendrites in functions such as spatial navigation/learning, working and associative memory, visual processing etc. The lab has recently expanded its research to include experiments in mice, whereby the role of dendrites in prefrontal functions is investigated via behavioral, electrophysiological and imaging techniques. The laboratory offers a thriving, ambitious research environment which is well funded from several grants.

    Benefits

    Vacancy terms: Full Time, Fixed Term from 1st October 2021 for 1 year

    Salary: Postdoc salary commensurate with experience: 26.000€ - 36.000€ per annum (monthly cost)

    Eligibility criteria

    Applications (full CV, statement of research interest and name and contact of 2-3 referees) should be sent by e-mail to orz0319@imbb.forth.gr, quoting “NEUREKA: PhD position (ORZ-0319)” in the subject line.

    The deadline for applications is midnight, August 20th, 2021 (GMT+2). Applications will be examined until the position is filled. Informal enquiries are welcome.

    Additional comments

    IMBB (www. imbb.forth.gr) is part of FORTH (www. forth.gr), one of the leading research foundations worldwide. IMBB is one of the most prominent life science research institutions in Greece, with an outstanding record of scientific achievements, state of the art infrastructure and a broad range of research, innovation and high quality, inspirational educational activities. In addition, IMBB is strongly committed to inclusivity, promoting equality and celebrating diversity among its staff and students.

    The wide-range of research activities in the Institute aim at understanding the basic biological processes operating in living organisms. IMBB also hosts interdisciplinary research programs at the interface of biology with informatics, chemistry, physics or medicine and is heavily involved in providing post-graduate students high-level education through joint graduate programs with the University of Crete. An additional standing mandate of IMBB is the exploitation and translation of acquired knowledge to tangible societal benefits, including the development of new technologies, innovative products and services.

    IMBB is located close to Heraklion which is the largest city and the administrative capital of the island of Crete, located south of the Greek mainland. It is the fifth largest city in Greece with a population of > 140,000 and is famous for its lively lifestyle and the outstanding outdoors.

    Offer Requirements
  • REQUIRED LANGUAGES
  • GREEK: Excellent

    ENGLISH: Excellent

    Skills/Qualifications

    We seek candidates holding a PhD in Neuroscience and a keen interest in Computational Neuroscience. They must be highly motivated and creative individuals who want to work in a dynamic, multi-disciplinary research environment and be willing to interact with both experimental and theoretical neuroscientists. Previous experience should demonstrate the ability to work independently (e.g. via designing and carrying out work with custom-built set ups) and provide a multidisciplinary training (e.g. knowledge of techniques beyond programming, such as advanced imaging of neuronal activity, ideally 2 photon calcium imaging, and behavioral assays). Experience or familiarity with related computational skills, including use of specialized software (ScanImage, ImageJ, IgorPro, Adobe Illustrator) and programming experience (Python, Matlab) is desirable. Candidates will also have the opportunity to become involved with computational modeling of neuronal circuits, which is well established in our lab.

    Specific Requirements

    Characteristics of the ideal candidate:

  • PhD in Neuroscience, Neurophysiology or a related subject.
  • Experience in developing, using and troubleshooting custom-built set ups (e.g. imaging and behavioral set ups)
  • Experience in advanced imaging techniques (2 photon calcium imaging and confocal imaging)
  • Experience in behavioral assays
  • IT skills in specialized packages (ScanImage, ImageJ, IgorPro, Adobe Illustrator) and programming experience (Python, Matlab)
  • Experience with analysis and processing of experimental data.
  • Experience in scientific writing/communication/presentations delivery/publishing (proven by a corresponding list of publications).
  • Fluency in spoken and written English and Greek.
  • Strong communication and interpersonal skills, being able to work comfortably both in a team and independently.
  • Ability to work with minimal supervision, prioritizing own workload to deal with urgent tasks, while maintaining a high standard of accuracy and attention to detail.
  • Willingness to travel.
  • Contact Information
  • Organisation/Company: Foundation for Research and Technology-Hellas
  • Department: Institute of Molecular Biology and Biotechnology
  • Organisation Type: Public Research Institution
  • Website: https:// www. imbb.forth.gr
  • Country: Greece
  • City: Heraklion
  • Postal Code: 70013
  • Street: Vassilika Vouton
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