N. 1 Senior Research Fellow According To Part. 24, Par. 3, Let. B), L. 240/2010 At Department Of...

Universities and Institutes of Italy

Italy

September 29, 2022

Description

  • Organisation/Company: Università degli Studi di Brescia
  • Research Field: Medical sciences › Medicine
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Leading Researcher (R4)
  • Application Deadline: 29/09/2022 23:59 - Europe/Brussels
  • Location: Italy › BRESCIA
  • Type Of Contract: Temporary
  • Job Status: Other
  • Offer Starting Date: 31/12/2022
  • Selective procedure for the calling of a Senior Research fellow, according to art. 24, paragraph 3, letter b), of the Law nr. 240/2010, for the Academic Recruiting Discipline 05/E1 - “General Biochemistry” Academic Discipline BIO/10 “Biochemistry” at Department of Molecular and Translational Medicine. Maximum number of scientific papers to be submitted: 12 (twelve). Project Title Alterations of endothelial cell metabolism as a therapeutic target of pathologies dependent on vascularization processes. Description of the research project The research project will focus on the characterization of the metabolic adaptations of endothelial cells in diseases in which the vascular component plays a pathogenetic role, such as cancers, diabetes, atherosclerosis and obesity. In particular, the close cross talk between extracellular matrix proteins, their organization and metabolic alterations that occur in endothelial cells as well as in tissue parenchyma cells will be studied. Assays for the study of energy metabolism and metabolic fluxes in vitro and in vivo will also be implemented, including high resolution imaging technologies, bioinformatics, and functional metabolic analyzes. The characterization of these alterations, of the metabolic adaptations and of the molecular mechanisms will allow the identification of new therapeutic targets. The aim of the research project will be the development of new therapeutic approaches aimed at restoring the physiological metabolism of the endothelial cell and restoring tissue homeostasis. Aims of the project will be: 1. Characterization of the effects of extracellular matrix modifications in the regulation of endothelial metabolism in physiological and pathological conditions. 2. Development of alternative models for the study / characterization of metabolic pathways in the endothelium. 3. Identification the mechanisms that regulate metabolic adaptations in endothelium-related diseases. 4. Development and validation of new therapeutic approaches aimed at restoring the physiological metabolism of the endothelial cell. Expected teaching activity The minimum number of working hours per year will be 1500. The teaching activity will concern the Biochemistry courses, in particular those for the Faculty of Medicine of the University of Brescia. The researcher will be asked to participate in exam committees, training activities with “laurea” students and help, support and tutoring for internship and research theses in biochemical sciences. The candidate will have to deal with all aspects of the project, including experimental, coordination and fund research. First of all, he will have to carry out characterization experiments of cellular and tissue metabolism in the development and progression of endothelium-related diseases in vitro, in vivo and ex vivo 7 using cellular and molecular biochemistry techniques, advanced confocal and two photons microscopies (FLIM/FRET) for the study of dynamics and of molecular interactions in cells and tissues, flow cytometry. In addition, the candidate will have to identify, develop and validate new therapeutic approaches in vitro and in vivo aimed at reverting endothelial metabolic alterations also through the use of transgenic animal models and patient- derived cells.

    Additional comments

    https: // www. unibs.it/it/ateneo/amministrazione/concorsi/procedure-di-rec...

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Medical sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Good

    Contact Information
  • Organisation/Company: Università degli Studi di Brescia
  • Organisation Type: Higher Education Institute
  • Website: https:// www. unibs.it
  • E-Mail: docenti-ricercatori@unibs.it
  • Country: Italy
  • City: Brescia
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