Multiplex Synthetic Biology Scientist

Universities and Institutes of France

France

February 25, 2022

Description

  • Organisation/Company: Lesaffre
  • Research Field: Biological sciences › Biological engineering Biological sciences › Biology Chemistry › Biochemistry
  • Researcher Profile: Recognised Researcher (R2) Established Researcher (R3)
  • Application Deadline: 25/02/2022 00:00 - Europe/Athens
  • Location: France › Marcq-en-Baroeul
  • Type Of Contract: Permanent
  • Job Status: Full-time
  • Offer Starting Date: 01/04/2022

  • Design large-scale microbial synthetic and systems biology experiments leveraging the full capabilities of the Lesaffre Biofoundry (numerous and highly integrated robots for high-throughput molecular biology, strain construction and strain characterization; high-throughput NGS sequencing ; and other capabilities) in order to accelerate DBTL cycles for a variety of industrial biotechnology applications

  • Together with other members of the Lesaffre Biofoundry, oversee the successful execution of these experiments. Participate in troubleshooting and propose solutions to resolve identified problems
  • Oversee the consolidation and analysis of all the data generated by these experiments, working with the bioinformaticians and data engineers from the Lesaffre Data Science team when relevant. Develop strategies to automate the design of future experiments based on all currently available data

  • Maintain world-leading knowledge in the field of microbial synthetic and systems biology. Detect opportunities to improve the efficiency and reliability of existing workflows or to develop new ones. More specifically, establish the combined use of large-scale DNA barcoded strain libraries (pooled or arrayed) with high-content, system-level data (such as transcriptome trajectories) as a powerful, generic tool that can be applied across the Lesaffre R&D project portfolio

  • Maintain high-quality documentation of your work and discoveries, in the forms of written reports, technical presentations, electronic lab notebooks, internal database records, code comments, and software documentation
  • Offer Requirements Specific Requirements
  • PhD or equivalent experience in genetics, genomics, synthetic biology, biochemistry, chemical engineering, bioengineering, or another related field. Interdisciplinary work is strongly encouraged
  • At least 4 years of experience in designing large-scale experiments leveraging DNA barcoding and multiplexed sequencing for applications in microbial synthetic biology or systems biology
  • Expertise in analyzing the results of such experiments using existing or custom-made computational pipelines
  • Proficiency in developing custom computational pipelines for a broad range of applications, preferably using Python and its open-source software ecosystem for biological applications (Biopython, the synthetic biology tool suite from the Edinburgh Genome Foundry…)
  • Expertise in programmatic data retrieval and treatment from public databases (UniProt, Brenda, KEGG…) as well as from internal databases (custom-built SQL databases, LIMS…)
  • Software engineering skills are a big plus
  • Expertise in the design of RNA-seq workflows (including library preparation and data analysis) is a big plus
  • Experience in leveraging lab automation equipment (liquid handling, thermocycling, colony picking, incubators, cytometers…) at the level of experiment design is a big plus
  • Ability to work in an international team, including good command of spoken and written English, cultural sensitivity, flexibility
  • Contact Information
  • Organisation/Company: Lesaffre
  • Organisation Type: Large Company
  • Website: https:// www. lesaffre.com
  • Country: France