MRC Postdoctoral Research Scientist in C omputational Genomics
£37,500 plus London allowances (£3,727 & £1,402) per annum
Fixed-term, 3 years
The Computational Regulatory Genomics Group headed by Prof Boris Lenhard studies gene regulation at the genome-wide level using methods of computational genomics and epigenomics. Members of our team have backgrounds in genetics, biochemistry, mathematics, computer science, machine learning, and clinical psychiatry. The group has a track record of excellence and innovation in computational biology and in applying and developing experimental techniques, with numerous publications in top-tier journals and extensive international collaboration. For more information, visit the group's website https:// group.genereg.net/.
Position summary : We are looking for a skilled and ambitious postdoctoral researcher with experience in computational genomics or a related field. In collaboration with the group PI, you'll devise a project aimed at unravelling the genome-wide molecular intricacies that govern transcription regulation. The project broadly seeks to delineate the fundamental grammar of promoter and enhancer sequences and the interacting proteins, particularly during embryonic development, differentiation, and cell cycle control in multicellular animals. By joining our team, you will engage with seminal questions in gene regulation, harnessing and refining the latest methodologies for genomics data analysis and visualisation. Once oriented with our group's objectives, you'll be encouraged to steer your project's course, fostering ample interactions and collaborations with experimental biologists.
Qualifications and motivation: You should ideally have a strong scientific curiosity, a demonstrated potential for independent high-impact research, as well as in-depth knowledge of molecular biology and evidence of programming skills and analysis of genomics data. Some of these skills will be tested during the interview process. Ideal candidates will have a robust background in computational genomics or a related field with a strong computational biology component. A history of successfully analysing, visualising, and disseminating high-throughput sequencing data is sought, coupled with a comprehensive understanding of molecular biology. Proficiency in R or Python, alongside experience in developing data analysis packages or pipelines (e.g., using Nextflow or Snakemake), is essential. Familiarity with Linux administration will be regarded favourably.
Academic and career benefits : Historically, the members of our group have gained world-class skills in computational genomics, data analysis and manipulation, and have moved on to independent academic positions, leading positions in applied bioinformatics, or successful careers in industry. You will be welcomed into our existing collaborations with high-profile researchers and international consortia, and will also have the opportunity to establish your own collaborations. You will be able to present your work at 2-3 international conferences per year.
Keywords : multicellular development, non-coding conservation, cell cycle control, long-range gene regulation, promoters, enhancer-promoter communication, computational genomics, epigenomics
The post is an MRC Postdoctoral Scientist position providing training and development, supporting post-doctoral scientists in early or changed career paths, helping establish them as successful research scientists in their chosen field. We offer a highly attractive benefits package including competitive salary, excellent holiday entitlement and generous pension scheme.
Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.
Final appointment will be subject to pre-employment screening.