Adult myofibers diversity, and more particularly their fast subtypes, is
finely controlled by
corresponding motoneuron (MN) diversity. Yet the determinants of this MN
diversity and how their
specific properties may finely tune the myofibers' phenotypes remain to be
overall goal of the project is to define the regulatory mechanisms determining
the crosstalk between
MN subtypes and myofiber subtypes that preside to the expression of a single
myosin heavy chain
(Myh) gene in the hundreds of nuclei present in a given fiber. The post-doc
will also work on
determining the mechanisms controlled by MN firing involved in the control of
cascades in the myofiber, and the mechanisms presiding to the differential
vulnerability of MN
subtypes observed in mouse models of human pathologies. Several complementary
models will be studied allowing the characterization of the molecular
mechanisms presiding the
dialog between motoneuron and myofiber subtypes.
This study will allow us to identify the transcription factors and signaling
pathways involved in those
mechanisms, especially with the complementary snRNA-seq and snATAC-seq
experiments that will
be performed on the existing or newly generated CRISPR/Cas9 mouse models.
Offer RequirementsSpecific Requirements
A curious and inventive post doc will be welcomed for a two years position.
He/she must have good
knowledge of the neuromuscular system and the big data analysis softwares.
Research Field: Biological sciences › Biology
Location: France › Bordeaux
metabolism rewiring and its molecular inter-patients and intra-tumor
Our data indicate that 1) pyrimidine biosynthesis pathway is upregulated
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Location: France › Montpellier
pathophysiology of the ocular defects.
generate iPSC lines knocked-out for 5 different albinism genes and
and biochemical levels to elucidate the role of OCA genes in disease
Location: France › Paris
Toubert group) has a long-standing interest in T-cell
repertoire and thymic function analysis in human immunology and
immunopathology, developing T cell Receptor Excision Circles (TRECs)
Team website : https: // irsl.u-paris.fr/umrs-1160-ecotaxie-micro-...
The objective of this project is to design an efficient cell and gene therapy
molecular mechanisms regulating muscle formation, this project will test
whether blood cells genetically modified to express fusion-promoting factors
can be used...