2 Nov 2023
Job InformationOrganisation/Company
Università di Pavia
Research Field
Other
Researcher Profile
Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)
Country
Italy
Application Deadline
30 Nov 2023 - 23:59 (UTC)
Type of Contract
To be defined
Job Status
Not Applicable
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No
Offer DescriptionThe DNA Damage Binding 2 (DDB2) is a protein participating in Nucleotide Excision Repair (NER), recognizing of UV-induced DNA lesions. Mutations in DDB2 gene determine the genetic disease Xeroderma pigmentosum of group E (XP-E), which is characterized by NER deficiency and a high risk to develop malignant skin tumors. DDB2 overexpression has been found in different tumors, suggesting that this protein may
promote cancer progression with a not well- defined mechanism. Moreover, DDB2 interacts with PCNA and, a DDB2 mutant unable to interact with PCNA is NER deficient, confers a proliferative advantage and promotes cell motility. However, the contribution of PCNA to DDB2 activity in tumors is still unclear. The goal of this project is to identify new molecular network comprising DDB2 and PCNA, which may help dissecting gene expression pathways leading to increased cell proliferation and acquisition of invasion ability in tumors
Requirements Additional InformationEligibility criteria
The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: https:// www-assegni.unipv.it/bandi-dipartimenti-tipo-b/ Main requirements are:1) degree (with a course duration of not less than 4 years, as referred to in the pre-existing academic regulations pursuant to D.M. n. 509/1999) or post-graduate degrees (pursuant to D.M. n. 509/1999 and to n. 270/2004) awarded by Italian or foreign Universities recognized as equivalent - for the purposes of establishing the equivalence, candidates must provide the necessary documentation to enable the evaluating board to proceed with the qualification assessment; 2) scientific or professional curriculum suitable for conducting the research activity; 3)if available, any Ph.D. title (Art 2- par. 1).
Further specific assessable qualifications (see Art. 6): 1) Master Degree preferentially in Medical and Pharmaceutical Biotechnologies or Experimental and Applied Biology;2) Proven research experience in molecular and cellular biology studies; 3) Proven experience in the management of human cell cultures; 4) Proven experience in the application of cell transfection techniques;5)Proven research experience in the field of molecular pathology; 6) Proven experience in the management and use of techniques for the evaluation of cell motility, invasion and metastatic capabilities as well as the interaction between proteins and epigenetic modifications; 7) Proven experience in the application of polyacrylamide gel electrophoresis in the presence of SDS (SDS-PAGE) and Western Blotting; 8) International publications on topics in molecular pathology.
Eligible destination country/ies for fellows:
Eligibility of fellows: country/ies of residence:
Eligibility of fellows: nationality/ies:
Selection process
The application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page:https: // pica.cineca.it/unipv by choosing the “Assegni di ricerca”; item and selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carried out on the basis of qualifications, project and interview, supplemented by a test of knowledge of the foreign language (see art. 6 - paragraph 1).The candidate selection will take place on the basis of the documented qualifications and a personal interview, completed by a test concerning the knowledge of foreign language (see Art. 6 par 1)
Website for additional job details
https:// www-assegni.unipv.it/bandi-dipartimenti-tipo-b/
Work Location(s)Number of offers available
1
Company/Institute
Università di Pavia
Country
Italy
Website
https: // pica.cineca.it/unipv
ContactCity
Pavia
Website
https: // portale.unipv.it/it
STATUS: EXPIRED