Mechanisms Of Primary Cilia Formation

Universities and Institutes of Czech

Czech Republic

October 31, 2022

Description

  • Organisation/Company: Masaryk University, Faculty of Medicine
  • Research Field: Medical sciences › Medicine
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 31/10/2022 00:00 - Europe/Brussels
  • Location: Czech Republic
  • Offer Starting Date: 01/03/2023
  • Affiliation: Masaryk University, Faculty of Medicine Study program: Ph.D. program Biomedical Sciences Specialization: Biochemistry and Molecular Biology Workplace: Department of Histology and Embryology Mode: Full-time Supervisor: Lukáš Čajánek, Ph.D. Lab web: https: // www. cajaneklab.com/ Title: Mechanisms of primary cilia formation Brief annotation: The primary cilium is an enigmatic, antenna-like organelle present on the surface of most cells. Whilst it was originally described as a vestigial organelle, recent years have indisputably proven its status as a seminal structure for sensing various extracellular stimuli. Primary cilia govern many important aspects of embryonic development as well as tissue homeostasis in adulthood. Consequently, deregulation of primary cilia assembly, maintenance, or function is linked to numerous human diseases, collectively termed ciliopathies. Components of basal bodies, such as Tau Tubulin Kinase 2, have recently emerged as crucial elements controlling various aspects of primary cilia formation and function. However, the mechanistic understanding of how the individual components act together to fulfill their indispensable role in cilia biology is lacking. The Ph.D. student will pursue a project intended to investigate the molecular mechanisms controlling the formation and maintenance of primary cilia, with the intention to bring insight into the processes governed by Tau Tubulin Kinase 2 at the basal body. The student pursuing this project will have an access to state-of-the-art methodology and instrumentation, including classical biochemical and cell biology approaches, proteomics, gene editing using CRISPR/Cas9, and advanced microscopy techniques (super-resolution microscopy, live cell imaging). Requirements: Master's degree in biological sciences or similar. The selected student should be motivated, curiosity-driven, eager to learn, and capable of critical thinking. Experience with cell biology techniques will be an advantage.

    Contact Information
  • Organisation/Company: Masaryk University, Faculty of Medicine
  • Organisation Type: Higher Education Institute
  • Country: Czech Republic
  • Similar Jobs

    Universities and Institutes of Czech

    Czech Republic 2 days ago

    Add to favorites Read more...

    Human Retinal Organoids As A Tool For Investigating Molecular Mechanisms Of Retinal Ciliopathies.

    Faculty of Medicine, Masaryk University, Brno, Czech Republic) Research topic: Human retinal organoids as a tool for investigating molecular University, Faculty of Medicine (https: // histology.med.muni.cz/bartalab). NGS, pluripotent stem cells, organoids). tissue culture of human...

    Add to favorites Read more...

    Postdoc In Telomere Biology (M/F)

    Research Field: Biological sciences › Biology extractions, and analyzes of nucleic acids and proteins) - Cell Biology the pathways causing replicative senescence induced by telomere length erosion and senescence to uncover the molecular basis of...

    Add to favorites Read more...

    Post-Doc

    Research Field: Biological sciences › Biology Location: Greece › Heraklion The mitotic spindle is a microtubule-based apparatus that is responsible Defects in spindle formation can novel phosphorylation sites on tubulin, which are essential for optimal...

    Add to favorites Read more...

    Phd Student In Biology (M/F)

    Research Field: Biological sciences Location: France › MONTPELLIER associated with a decreased number of PC on colonic fibroblasts (Rocha et al. of PC and associated pathways in CRC. in the regulation of intestinal homeostasis and...

    Add to favorites Read more...

    Postdoctoral Position In Cell Biology, Membrane Dynamics And Epithelial Homeostasis

    Research Field: Biological sciences › Biology work on the role of membrane contact sites and autophagy interplay in the focused on molecular and cellular aspects of stress response and autophagy Key-words: autophagic machinery, contact sites,...

    Add to favorites Read more...

    Postdoctoral Position In Protein Design In The Hebrew University Of Jerusalem

    sciences › Biology Chemistry › Biochemistry Physics › Biophysics Location: Israel › Jerusalem Postdoctoral position in Protein Engineering in the Hebrew University of Jerusalem is an international and interdisciplinary group located at the in the...

    Universities and Institutes of Czech

    Czech Republic 2 days ago

    Add to favorites Read more...

    Mesenchymal Stromal Cells For Neurological Disorders

    Affiliation: Masaryk University, Faculty of Medicine Study program: PhD Stem cell-based regenerative medicine is becoming an The unique characteristics of mesenchymal stem cells (MSCs) make them among Organisation/Company: Masaryk University, Faculty of Medicine Organisation/Company: Masaryk...