Life Science Research Professional 2

Stanford University

United States

November 7, 2021

Description

Stanford University is seeking a Life Science Research Professional 2 to perform more complex functions and activities involved in defined research projects, and independently conduct a portion of the research project(s).

About the Position

We are looking for highly motivated individuals to join our laboratory to perform technology-driven research in a dynamic and exciting environment. This position provides long-term career development opportunity, and we have outstanding track record (alumni at leading institutions such as Harvard/MIT, or obtained highly-competitive positions at Biotech companies).

The successful candidates will work directly with the PI (Dr. Le Cong) and a team of talented trainees, be co-authors on published work, and gain valuable bench and management expertise in our inter-disciplinary group. There is opportunity to engage in clinical-relevant research, and we will provide training on computational and data analysis skills with senior members. We encourage applicants who are willing to take on this incredible opportunity and generate impact at the interaction of (1) gene-editing and single-cell screening (2) computational genomics and machine learning (3) neuro- immunology research.

About the Lab

In the lab of Dr. Le Cong at Stanford (Dept. of Pathology and Dept. of Genetics, Wu-Tsai Neuroscience Institute and Stanford Bio-X Institute), the overarching goal is to develop cutting-edge gene-editing and single-cell technology to understand complex diseases. We integrate machine learning (ML) and computational tools, and apply the technologies to disease-relevant models.

The lab's research focuses on inventing gene-editing tools with computationally-inspired method beyond natural CRISPR system ( JACS 2019, Nucleic Acid Research 2021 ). Using novel gene-editors, we are performing single-cell screening to unbiased understand disease-causing mutations. We combine the power of genome engineering, machine learning ( ICML 2020 ), and single-cell genomics ( Cell 2017, Cell Reports 2019 ) to understand complex disease mechanisms. We have a particular focus on using cancer and stem cell models ( Cancer Discovery 2020, Trends in Genetics 2021 ). To learn more about the investigators, please see our group's website ( www. conglab.com ) and Dr. Cong's profile ( https: // profiles.stanford.edu/186687 ).

Recent work include:

-New Gene-editing Technology

(Nucleic Acid Research 2021, Molecular Therapy 2020, JACS 2019)

-Single-cell and Computational Biology

(ICML 2020, Cell Reports 2019, Cell 2017)

-Stem Cell and Disease Modeling

(Trends in Genetics 2021, Cancer Discovery 2020)

We are a highly innovative team collaborating with expert groups in cancer immunology, stem cell biology, and neuroscience. This will be a unique opportunity to learn and grow in research, biotechnology development, and translational applications.

Duties include:

  • Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
  • Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
  • Interpret and analyze results, and make modifications to existing procedures and protocols. Develop new research protocols where appropriate protocols are not described in the literature.
  • Participate in multidisciplinary teams across different faculties or schools.
  • Perform ongoing literature review to remain current with new procedures and related research.
  • Contribute substantively to the preparation of papers for publication. Present work to colleagues and/or conferences.
  • Supervise (either formally or informally) staff or students as needed. Serve as a technical resource for other research staff.
  • Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
  • - Other duties may also be assigned

    DESIRED QUALIFICATIONS:

  • Degree in molecular biology
  • Experience with and ability to learn new experimental, computational, and statistical skills.
  • Experience with basic rodent handling and animal husbandry.
  • Take initiative to recognize and fill areas in the lab that need improvement.
  • Theoretical knowledge of molecular biology, gene-editing, and next generation sequencing.
  • Ability to communicate effectively with people of all technical and scientific backgrounds.
  • Excellent organizational, interpersonal and communication skills.
  • Experience with tissue culture, flow cytometry, and basic molecular cloning and cell biology techniques.
  • EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.

    KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

  • Comprehensive understanding of scientific principles.
  • General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
  • Strong analytical skills and excellent judgment.
  • Ability to maintain detailed records of experiments and outcomes.
  • Ability to work under deadlines with general guidance is essential.
  • Excellent organizational skills and demonstrated ability to accurately complete detailed work.
  • CERTIFICATIONS & LICENSES: None

    PHYSICAL REQUIREMENTS:

  • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
  • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
  • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
  • Must have correctible vision to perform duties of the job.
  • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
  • Ability to lift heavy objects weighing up to 50 pounds.
  • Ability to work in a dusty, dirty, and odorous environment.
  • Position may require repetitive motion.
  • - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

    WORKING CONDITIONS:

  • May require working in close proximity to blood borne pathogens.
  • May require work in an environment where animals are used for teaching and research.
  • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
  • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
  • May require extended or unusual work hours based on research requirements and business needs.
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