LAB RESEARCH ANALYST II
Requisition Number:: 126108
Date: Jun 10, 2021
Durham, NC, US, 27710
Personnel Area: MEDICAL CENTER
School of Medicine:
Established in 1930, Duke University School of Medicine is the youngest of the
nation's top medical schools. Ranked tenth among its peers, the School takes
pride in being an inclusive community of outstanding learners, investigators,
clinicians, and staff where traditional barriers are low, interdisciplinary
collaboration is embraced, and great ideas accelerate translation of
fundamental scientific discoveries to improve humanhealth locally and around
Comprised of 2,400 faculty physicians and researchers, the Duke University
School of Medicine along with the Duke University School of Nursing and Duke
University Health System create Duke Health. Duke Health is a world-class
health care network. Founded in 1998 to provide efficient, responsive care,
the health system offers a full network of health services and encompasses
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke
Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health
and Wellness, and multiple affiliations.
Lab Research Analyst II (LRA II)
Seeking a self-starting scientist with good problem-solving skills and
strengths in quantitative analysis, particularly by LC-MS/MS. Job duties will
be to work in a fast-paced, team-based environment to conduct a variety of
complex and independent investigations addressing physical, chemical, and
other research laboratory experiments to obtain and interpret data for
research projects at Duke, specifically addressing metabolomics and proteomics
in cancer, neurodegenerative diseases, and infectious diseases. Scientific
integrity, curiosity, and determination are key qualities of a successful
In particular, the Lab Research Analyst II will conduct a variety of complex
laboratory procedures and specialized laboratory techniques for the analysis
of endogenous metabolites, drug molecules, peptides and proteins in the
Proteomics and Metabolomics Core Facility for the School of Medicine. Note
that both SOP-driven and independent analyses will be required, and proven
analytical thinking and problem-solving skills are critical. The ability to
effectively work in a multidisciplinary team environment and move easily from
one task to another is essential.
Tasks may include:
1) 40% - Preparation of biological samples for metabolomic, proteomic, and
2) 30% - Quantification of metabolites using triple quadrupole mass
spectrometry, and contribution to the development of new LC-MS/MS assays.
Validation of figures of merit for quantitative LC-MS/MS assay.
3) 10% - Protein identification and quantitation using nanoscale capillary
liquid chromatography and analytical scale liquid chromatography coupled with
either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS)
or triple quadrupole mass spectrometers operated in MRM mode.
4) 15% - Contribution to written reports and publications of results in
collaboration with investigators inside and outside of Duke. Review journals,
abstracts, and scientific literature to keep abreast of new developments and
to obtain information regarding previous experiments to aid in the design and
development of original procedures and techniques.
5) 5% - Presentation of their ongoing work at group meetings and national
meetings, and critical evaluation of new approaches for metabolomics and
proteomics presented in the literature or by others.
Work requires a bachelor's degree in chemistry, biochemistry, biology or other
directly related scientific field. A related master's degree or PhD may offset
required years of experience on a 1:1 basis, e.g., a two-year master's degree
in lieu of two years of experience.
Experimental design/planning, sample preparation, LC-MS/MS sample analysis and
results interpretation skills are essential. Additional skills in statistics,
bioinformatics, or programming are a plus.
Duke is an Affirmative Action/Equal Opportunity Employer committed to
providing employment opportunity without regard to an individual's age, color,
disability, gender, gender expression, gender identity, genetic information,
national origin, race, religion, sex, sexual orientation, or veteran status.
Duke aspires to create a community built on collaboration, innovation,
creativity, and belonging. Our collective success depends on the robust
exchange of ideas—an exchange that is best when the rich diversity of our
perspectives, backgrounds, and experiences flourishes. To achieve this
exchange, it is essential that all members of the community feel secure and
welcome, that the contributions of all individuals are respected, and that all
voices are heard. All members of our community have a responsibility to uphold
Essential Physical Job Functions: Certain jobs at Duke University and Duke
University Health System may include essentialjob functions that require
specific physical and/or mental abilities. Additional information and
provision for requests for reasonable accommodation will be provided by each
Nearest Major Market: Durham
Nearest Secondary Market: Raleigh