Description

Organisation/Company: IBMC

Research Field: Biological sciences

Researcher Profile: First Stage Researcher (R1)

Application Deadline: 01/07/2022 23:00 - Europe/London

Location: Portugal › Porto

Type Of Contract: Other

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 01/09/2022

Eu Research Framework Programme: H2020

Reference Number: WIDESPREAD-2020-06

The IBMC/i3S opens a tender procedure for the selection of 1 Junior Researcher, working in the field of Host-microbe interactions. Candidates should meet the criteria of "Recognized Researchers (R2)" established in the European Framework for Research Careers. The appointment will be made as part of the ImmunoHub project: An Immunological Hub of Excellence in Porto tailored to fulfil the ERA Priorities AT IBMC/I3S, funded by the European Commission under the topic WIDESPREAD-2020-06 - ERA Chairs.

1. INTERNAL REFERENCE:JUNIORRESEARCHER/ERACHAIRIMMUNOHUB/IBMC/2611/2021

2. PROJECT SUMMARY:

The Immune Sensing and Signaling Dynamics group, led by Dr. Pedro Moura Alves, is seeking an exceptional and motivated postdoctoral scientist with experience in studying host-microbe interactions to undertake a project focused on the role of the Aryl Hydrocarbon Receptor (AHR) as an innate immune sensor of the cellular microenvironment during the course of infection. Dr. Moura-Alves recently demonstrated that the AHR acts as a dynamic and key host sensor of bacterial communication and infection dynamics (Moura-Alves, P et.al Nature 2014; Moura-Alves,P. et al Science 2019). While continuing to further dissect and evaluate how the AHR is involved in monitoring host-microbe interactions and regulating immune responses, the laboratory is expanding the studies to explore this dynamic crosstalk in greater detail, monitoring the continuous and coexisting adaptive processes in host and microbes simultaneously. This project aims to study the importance of the AHR in sensing and shaping immune responses that are appropriate to the infection stage and the related impact on bacterial adaptation strategies during the course of infection. By uncovering the mechanisms that allow hosts and bacteria to spy on each other, this work will open up new possibilities for the development of novel therapies to control infection and infection-associated diseases.

Contact Information

Organisation/Company: IBMC

Organisation Type: Other

Website: https: // www. ibmc.up.pt/

Country: Portugal

City: Porto

State/Province: Portugal

Postal Code: 4200-135

Street: Rua Alfredo Allen 208