Joint Phd France-Australia : Analysing The Conformations Of The Atpase P97 Using Cryogenic Electron... (# Of Pos: 2)

Universities and Institutes of France

France

September 30, 2022

Description

  • Organisation/Company: Sorbonne Université
  • Research Field: Biological sciences › Other
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 30/09/2022 23:00 - Europe/Brussels
  • Location: France › ParisAustralia › Melbourne
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • We are looking for a candidate for a joint PhD between the University of Melbourne (Melbourne, Australia) and Sorbonne University (Paris, France), on the subject of analyzing the conformations of the ATPase p97 using cryogenic electron microscopy (cryo-EM) and new image processing and modeling methods.

    The AAA ATPase p97 is a molecular machine that converts energy stored in ATP into conformational changes to segregate proteins in a variety of essential cellular processes, ranging from protein degradation, gene transcription and membrane fusion. Molecular machines or protein complexes, such as p97, exist in multiple conformations and their biological functions are driven by their ability to switch between conformations. Cryo-EM is a technique that allows studying molecular machines in native conditions and, as such, it is able to capture the full-range of conformations they adopt.

    The PhD candidate will study the conformational dynamics and determine the conformational landscape of p97 in vitro (purified protein) and in situ (in cells). Also, the PhD student will participate in the development of new image processing and modeling methods for analyzing the conformational dynamics of p97, which should also be useful for analyzing the dynamics of other protein complexes.

    If you have a background in biochemistry/biophysics, programming knowledge, and a keen interest in protein science, this is the project for you! You will learn how to prepare samples suitable for cryo-EM analysis, collect and analyze single particle and tomography data. You will also contribute to the development of image analysis and computational methods to analyze the conformational dynamics of protein complexes. The techniques that you will develop are at the leading edge of protein science and should revolutionize our current understanding of the protein world.

    This joint PhD will be funded by the University of Melbourne and requires mobility between the two universities (the University of Melbourne and Sorbonne University). The successful candidate will need to be accepted by both and enroll at both universities. Only the candidates with excellent grades and English level should apply.

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: Master Degree or equivalent

    Computer science: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Excellent

    Skills/Qualifications

    Background in biochemistry or biophysics and programming knowledge.

    Specific Requirements

    This is an offer for a joint PhD between the University of Melbourne (Melbourne, Australia) and Sorbonne University (Paris, France), funded by the University of Melbourne. The candidate should be accepted to enroll at both the University of Melbourne and Sorbonne University. Only the candidates with excellent grades and English level should apply.

    Contact Information
  • Organisation/Company: Sorbonne Université
  • Department: Faculty of Science and Engineering - IMPMC - Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie
  • Organisation Type: Higher Education Institute
  • Website: https:// impmc.sorbonne-universite.fr/fr/index.html
  • Country: France
  • City: Paris
  • Postal Code: 75252
  • Street: 4 place Jussieu
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