Interaction Entre Les Plasticités Synaptique Et Structurale

Universities and Institutes of France

France

November 15, 2021

Description

  • Organisation/Company: CNRS UMR5297
  • Research Field: Psychological sciences › Psychology
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Leading Researcher (R4)
  • Application Deadline: 15/11/2021 00:00 - Europe/Athens
  • Location: France › bordeaux
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Offer Starting Date: 01/12/2021
  • The objective of this thesis is to use our technological advance in imaging coupled with electrophysiology to revisit the LTD. In particular, we will redefine the respective modifications in the organization and dynamics of AMPARs in synaptic transmission during the early and sustained phases of LTD. This will pave the way for new approaches to controlling LTD. In parallel, we will describe the structural plasticity induced by LTD. We will then determine the molecular link between these two plasticities.

    • Use our super-resolution imaging techniques in living and fixed tissues to characterize the organization and dynamics of AMPARs at the nanometric scale;

    • Combine calcium imaging to highlight active synapses with super-resolution imaging and electrophysiology to correlate the content of synaptic AMPARs with the strength of the associated synaptic response;

    • Use a recently characterized molecular tool allowing the immobilization of AMPARs both in brain slices and in vivo;

    • Develop a long-term fluorescence imaging technique to follow structural plasticity both in cell culture and in brain slices.

    Funding category: Contrat doctoral

    PHD title: doctorat de neuroscience

    PHD Country: France

    Offer Requirements Specific Requirements

    Le candidat doit avoir de solides bases en neuroscience et une forte motivation, des compétences autour de l'imagerie et/ou de la physiologie de la synapse sont préférables.

    Uniquement des personnes ayant un master2 ou équivalent pourront être recrutés

    Contact Information
  • Organisation/Company: CNRS UMR5297
  • Organisation Type: Public Research Institution
  • Website: https: // www. iins.u-bordeaux.fr/projectCHOQUET16
  • Country: France