27 Oct 2023Job Information
First Stage Researcher (R1)
31 Jan 2024 - 23:59 (Europe/Vienna)
Type of Contract
Hours Per Week
Is the job funded through the EU Research Framework Programme?
HE / MSCA
Marie Curie Grant Agreement Number
Is the Job related to staff position within a Research Infrastructure?
Short overview of the program:
IgG4-TREAT consortium is l ooking for highly motivated and talented PhD students to contribute to groundbreaking research in the field of IgG4-autoimmune diseases (IgG4-AID). The PhD researchers will have the opportunity to participate in a comprehensive training programme in academic and industry setup. Next to their transferable skills training, the IgG4-TREAT PhD students will pursue 10 individual, multidisciplinary research projects (organised into four scientific work packages) aimed to advance our understanding of IgG4-AID.
PhD candidates will become part of a network of 9 host laboratories and 7 associated partners from 7 different European countries. Funding for these projects has been provided by the EU under the competitive MSCA Doctoral Networks 2022 program (Grant Agreement No. 101119457). For more information on IgG4-TREAT visit our website: https: // www. igg4-treat.eu/.
Project R2: Identification of specific serum biomarkers and immune cell dysregulation commonly associated with IgG4 autoimmune diseases
Hosting lab + location:Dr Rozen Le Panse's Team at the Center of Research in Myology – INSERM/Sorbonne University – Hospital Pitié-Salpêtrière, Paris, France
Research project description:
IgG4 autoimmune diseases (IgG4-AID) are a group of severe autoimmunopathies that are characterized by pathogenic IgG4 autoantibodies against defined target antigens. To better understand IgG4-AID, we plan to identify specific serum biomarkers and immune cell dysregulation commonly associated with IgG4-AID.
Our team has a long-time expertise in autoimmune Myasthenia Gravis (MG) including MuSK MG mediated by IgG4 autoantibodies. The PhD project proposed in our laboratory will investigate serum biomarkers associated with IgG4-AID using the Olink technology that allows the analysis of at least 384 serum proteins per sample. In parallel, immune cell dysregulation in IgG4-AID will also be investigated by mass cytometry (CyTOF). These multiparametric analyses will be performed by comparing healthy donors with anti-MuSK-MG patients, but also anti-LGI1 encephalitis patients obtained from partners of the IgG4-AID network. Specific serum biomarkers and immune cell dysregulation will be further validated in other IgG4-AID by the PhD student during a secondment at TND (Tzartos NeuroDiagnostics, Greece) (ELISA and SIMOA analyses) or by different partners. In addition, the implication of defined immune dysregulation will be investigated by flow cytometry in the experimental MuSK-MG mouse models in a secondment at Istanbul University (supervised by V. Yilmaz and E. Tüzün, Turkey).
Methods used in the project: Mass and flow cytometry, Protein analyses (ELISA, SIMOA…), Bioinformatics skills for multiparametric analyses, Human blood sample preparation, Animal work during a secondment
Project duration: 36 months (35h/week)
Hosting lab description:
Dr Rozen Le Panse's team is part of the Center of Research in Myology located in Paris (hospital Pitié-Salpêtrière). She has been working on Myasthenia Gravis for more than 20 years. The team is investigating the etiological and pathophysiological mechanisms involved in MG. The team is also involved in the search for new therapeutic approaches using different experimental models. In collaboration with clinicians working on Myasthenia Gravis, the team is also looking for new cellular and molecular biomarkers for the follow-up of the patients using new technological approaches. More information on Le Panse's team.
Foreseen mobility: Secondments are planned in:
Master Degree or equivalent
Master Degree or equivalent
The funding is guaranteed for 36 months and will include:
Allowances are gross amounts , which means that all compulsory social security contributions, direct taxes, and any other compulsory deductions under national legislation will be deducted from these amounts.
How to apply:
Interested candidates can find more information on the consortium website. Candidates can apply for up to three positions and should indicate their preferences in the application form. To apply, please send the following application documents as a single PDF file to [email protected]. As the subject of your email, please use IgG4-TREAT application-your last name.
CV (in Europass or ORCID format) including any publications, prizes/grants obtained, and international experience. The candidates are asked to highlight any extra-professional activities to measure leadership, creativity, communication abilities, etc. as well as their hobbies.
Motivation letter : 1 page highlighting the main expertise of the applicant, career plans and motivations for the program.
All documents need to be provided in English. We aim for a maximum level of inclusiveness in our recruitment, and to reduce the risk of any bias, we ask that candidates focus only on their academic qualifications and make sure that no information on biological sex, gender identity, age, ethnicity, or sexual orientation is included in the application documents (with the exception of the application form).
The selection procedure will be open, transparent, merit-based, and in line with the Code of Conduct for the Recruitment of Researchers. All the network institutions are equal opportunity employers and seek a workforce diverse in age, culture, nationality and gender.
The application process will start in October 2023. The deadline for applications is 31/01/2024. The individual projects are set to start between 31/03/2024 and 01/09/2024.
The selection process will consist of several steps. First, we will check if the applications are complete and if the applicants fulfill the eligibility criteria. Then, each eligible application will be evaluated by the prospective supervisors, according to project preferences indicated by the applicant. Shortlisted candidates will be invited for the next steps of the application process including several rounds of online interviews with prospective supervisors and other supervisors from the network. Successful candidates will be informed within a few weeks after the interviews.
Website for additional job details
https: // www. igg4-treat.eu/apply/Work Location(s)
Number of offers available
Center of Research in Myology – INSERM/Sorbonne University, Paris, France
105 Boulevard de l'Hôpital
GeofieldWhere to apply
https: // www. igg4-treat.eu/apply/Contact
https: // www. igg4-treat.eu/
https: // recherche-myologie.fr/research/labs/le-panse- lab/?lang=en#tabsequipe1
105 Boulevard de l'Hôpital