Human Retinal Organoids As A Tool For Investigating Molecular Mechanisms Of Retinal Ciliopathies.

Universities and Institutes of Czech

Czech Republic

October 31, 2022

Description

  • Organisation/Company: Masaryk University, Faculty of Medicine
  • Research Field: Medical sciences › Medicine
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 31/10/2022 00:00 - Europe/Brussels
  • Location: Czech Republic
  • Offer Starting Date: 01/03/2023
  • Study program: Biomedical Sciences Specialization: Cell and Tissue Morphology Supervisor: Tomáš Bárta, Ph.D. (Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic) Research topic: Human retinal organoids as a tool for investigating molecular mechanisms of retinal ciliopathies. We are seeking a talented and motivated PhD student to join a research team headed by Dr. Tomas Barta at Masaryk University, Faculty of Medicine (https: // histology.med.muni.cz/bartalab). The successful candidate will have the opportunity to perform research in the area of molecular mechanisms of human ciliopathies with a special focus on retinal inherited diseases using human retinal organoids as a model. The major research focus is on the mutations in genes coding for regulators of the retinal and primary cilia maintenance. However, contribution to other research projects that use human retinal organoids to address other aspects of human retinal physiology is also anticipated. The selected candidate will have access to state-of-the-art methodology and instrumentation (live imaging, lentiviral gene delivery, gene editing, high-resolution confocal microscopy, NGS, pluripotent stem cells, organoids). We offer: • to gain experience in tissue culture of human pluripotent stem cells and organoid generation • to generate patient-specific human induced pluripotent stem cells and CRISPR/Cas technology • to learn new methods • friendly environment of young enthusiastic group with international collaborations • to gain experience in grant proposal and manuscript writing • partial salary + stipend We require: • MSc in molecular or cell biology • familiar with basic molecular, cell, and biochemical methods • interest to learn new methods • able to work independently • critical thinking • experience with pluripotent stem cells and organoids is an advantage How to apply? Send a cv and a brief letter of interest to Tomáš Bárta (tbarta@med.muni.cz) until 23. October 2022. After the first round of the selection process, the selected applicants will be invited to submit their PhD application to university system.

    Contact Information
  • Organisation/Company: Masaryk University, Faculty of Medicine
  • Organisation Type: Higher Education Institute
  • Country: Czech Republic
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