Horizon-Msca-2021-Dn-01. Phd Position No. 10 "Mscs-Laden Scaffolds For Osteochondral Repair"....

Universities and Institutes of France

France

October 28, 2022

Description

  • Organisation/Company: Université de Montpellier
  • Research Field: Biological sciences › Biology Chemistry › Organic chemistry Engineering › Biomaterial engineering
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 18/11/2022 18:13 - Europe/Brussels
  • Location: France › Montpellier
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/02/2023
  • Eu Research Framework Programme: HE / MSCA
  • Reference Number: 101072645 — NANOREMEDI
  • Marie Curie Grant Agreement Number: 101072645
  • Marie Skłodowska-Curie Doctoral Network NANOREMEDI-programme in “Functional Nano-Scaffolds for Regenerative Medicine” stems from six Doctoral Courses/Schools at six beneficiary institutions, providing research and training in the field of nanomaterials for Regenerative Medicine. An active contribution of enterprises in training activities is a relevant feature of the programme.

    Beneficiaries (Doctorate Courses/Schools): University of Milan (Pharmaceutical Sciences), ITALY – Coordinating University; Universitat Politècnica de Catalunya (Polymers and Biopolymers) SPAIN; The Hebrew University Jerusalem (School of Chemistry), ISRAEL; Université de Montpellier (Balard Chemical Sciences doctoral school), FRANCE; University of Pavia (Bioengineering, Bioinformatics & Health Technologies), ITALY; IC nanoGUNE (Materials Physics; delivered by University of the Basque Country - Associated Partner linked to NANOGUNE beneficiary), SPAIN.

    Associated partners for secondments activities: Bayer Health Care Pharmaceuticals – ITALY; Edelweiss Connect GMBH – SWITZERLAND; Italfarmaco S.p.A. (CHEMI) – ITALY; Jacobacci & Partners – ITALY; Lynxter -FRANCE; Simune Atomistics SL – SPAIN; Ponti & Partners, SLP – SPAIN; AbMedica – ITALY; DeLama – ITALY; Officine Innovazione Srl (Deloitte) – ITALY; Genepep – FRANCE; BioBasic Europe rsl - ITALY

    The scientific approach proposed by NanoReMedi Consortium is strongly multidisciplinary and will involve a number of different state-of-the-art technologies and methodologies. Expected results are:

  • Generate tissue engineered vascular grafts (VGs) to replace damaged peripheral arteries
  • Study stem-cell based regenerative medicine for bone and cartilage repair
  • Ftakle implantation failure of engeneered tissues/scaffolds
  • 13 ESR PhD positions are offered by the Consortium related to different and multidisciplinary projects strongly interconnected involving different state- of-the-art technologies and methodologies: Computational chemistry; Chemical synthesis/peptide synthesis; Peptide based Nanomaterials (Soft materials/Hydrogels/Electrospinning) preparation and spectroscopic characterization; Production of vein graph; 3D-tissue fabrication; Biofilm prevention; Electrostimulated release of antimicrobial peptides

    Each ESR will attend the following training activities: i) advanced courses and soft and transferable skill courses provided by University's doctorate courses/schools; ii) multidisciplinary courses/Summer delivered by NanoReMedi Network at the general Network Meetings/; iii) Nine-months secondment at one of the Beneficiary jointly awarding the doctoral degree to improve research methods complementary to those at home institution; iv) Three-months secondment at one of the enterprise where ESRs are expected to acquire complementary skills.

    Job summary

    One position is available at the University of Montpellier, France, in research project n°10. Project Title: MSCs-laden scaffolds for osteochondral repair

    Objectives : Development of bi-functional scaffolds allowing both bone and cartilage synthesis in a spatially controlled manner

    Activities :

    1) Synthesis of hybrid hydrogels by introduction of triethoxysilanes onto biopolymers (chitosan/gelatin/hyaluronan) and bioactive peptides

    2) Preparation of functional hybrid hydrogels by the sol-gel process.

    3) Characterization of the hydrogels: physicochemical (mechanical properties, stability/degradation, swelling) and biological (cytotoxicity, cell adhesion, proliferation, differentiation)

    4) Cell encapsulation within the hydrogels

    5) 3D printing of the cell-laden hydrogels into multi-layer scaffolds

    Planned secondments:

    9 months of secondment at UMIL for Tuning of hydrogels performance by insertion of unnatural amino acids and/or molecular scaffolds

    3 months of enterprise secondment at Lynxter for 3D printing optimisation

    Benefits

    Benefits

    Each ESR will receive a 36-month grant to cover his/her participation costs, living, travel and installation allowance, family allowance, as follows:

    Living allowance 3.957,60€/month (This amount varies because of the application of a correction coefficient to the living allowance of the country in which the researcher will be recruited.)

    Mobility allowance 600€/month

    Family allowance 495€/month

    Total grant (36 months) 184.893,60€

    The cost of the PhD educational activities, as well as all expenses related to travels performed to attend schools, workshops, and network-organized events, will be planned and sustained by the network through the HORIZON EUROPE MSCA- DOCTORAL NETWORK grant (Institutional Costs).

    The ESR will be provided with office space and all facilities for his/her research programme.

    Eligibility criteria

    There are strict eligibility requirements for the ESR positions in MSCA-DN. Please ensure to be qualified before applying, as ineligible candidates cannot be considered.

  • Admission to the programme is open to applicants who hold a 2nd Level Master Degree (120 ECTS + 180 ECTS in a bachelor degree) or a Single Cycle Degree (minimum 300 ECTS), or a comparable university degree (Second Cycle qualification), as required by the partner universities for admission to doctoral studies. Applicants are expected to achieve their degree within November 28th, 2022. They shall submit a certified copy of any degree achieved by the deadline of January 31st, 2023.
  • Requirements set by the Consortium concern master's degree (or equivalent) graduates in the fields of computational chemistry, organic chemistry, materials chemistry, materials engineering, chemical engineering, pharmaceutical chemistry, pharmacy, biotechnology, biomedical engineering.
  • Applicants are required to be proficient in the English language (at least B2 level).
  • Applicants should – at the time of recruitment – be in the first four years (full time equivalent research experience) of their research careers not yet have been awarded a doctorate. They must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organization for more than 12 months in the 3 years immediately before their recruitment date. Compulsory national service and/or short stays such as holidays and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.
  • The Recruitment board will pay special attention to respect gender balance.

    Selection process

    The ESR will be selected on the basis of the following criteria (in random order):

  • scientific skills and research experience;
  • ability to collaborate and communicate;
  • career profile and potential for excellence;
  • expected impact of the proposed training on their career;
  • research project.
  • Additional comments

    Applications must be submitted on www. nanoremedi.eu/APPLICATION by October 28th, 2022 at 17:00 central European time (https:// www. timeanddate.com/time/zones/cet) within November 27th 2022 at 17:00 central European time.

    Applicants are required to submit the following documents by uploading them as a PDF file along with (or as one PDF attachment to) the application form. Instructions on submission are provided on www. nanoremedi.eu/APPLICATION. For more information you may also contact nanoremedi@nanoremedi.eu

    Hand written applications and applications sent by email, post or fax will not be accepted.

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Chemistry: Master Degree or equivalent

    Skills/Qualifications

    Chemical synthesis

    Materials characterization

    Cell culture

    Contact Information
  • Organisation/Company: Université de Montpellier
  • Department: Institut des Biomolécules Max Mousseron
  • Organisation Type: Public Research Institution
  • Website: https: // ibmm.umontpellier.fr/ https: // ibmmpeptide.com/
  • E-Mail: cecile.echalier@umontpellier.fr
  • Country: France
  • City: Montpellier
  • Postal Code: 34000
  • Street: Place Eugène Bataillon
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