H/F Cdd Doctorant

Universities and Institutes of France

France

August 16, 2022

Description

  • Organisation/Company: CNRS
  • Research Field: Chemistry › Physical chemistry Physics › Biophysics Physics › Chemical physics
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 16/08/2022 23:59 - Europe/Brussels
  • Location: France › CHATENAY MALABRY
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/10/2022
  • The Ph.D thesis will be performed at the Institut Galien Paris Saclay UMR CNRS 8612

    Type II diabetes and associated cardiovascular risks are considered major public health issues. Type II diabetes could be related to the aggregation of the human amyloid peptide (hIAPP or amylin) and its deposition in the pancreatic β cells, leading to their degeneration. Currently, there is no treatment to prevent the formation and deposition of these hIAPP oligomers in pancreatic cells. In this context, the Ph.D candidate will be involved in the development of an innovative polymeric nanomaterial (NM), so-called « Janus » with two faces, one allowing the in vivo capture of hIAPP and its circulating oligomers, and the other the binding of human serum albumin (HSA) for prolonged circulation in the blood. Therefore, this thesis aims at; (i) characterizing the interactions of this nanomaterial functionalized by ligands able to bind hIAPP selectively, with hIAPP, its oligomers and HSA using different complementary techniques available at IGPS and IPCM (such as Isothermal Titration Calorimetry, circular dichroism spectroscopy, zeta potential measurements, electron microscopy,…..), (ii) predicting NM's behavior in vivo, by studying the interactions that can be established in a complex biological medium such as blood, (iii) evaluating their biological behaviors (culture cells and in vivo). For this purpose, the doctoral student will characterize the interactions of the nanomaterials with hIAPP and HSA in biological fluids. The influence of blood proteins will be also investigated. The second part of the Ph.D. will be dedicated to biological and in vivo experiments (i.e. cytotoxicity, biodistribution, and pharmacokinetic studies). The PhD will benefit from different t platforms (circular dichroism, HPLC-MS, etc.) located at the faculty of pharmacy and from the multi-disciplinary skills of the collaboration (ANR JAROD) in terms of chemistry, physicochemistry, and biology.

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/Doctorant/UMR8612-MYRTAV0-002/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Chemistry › Physical chemistry

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Physics › Chemical physics

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Physics › Biophysics

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Chemistry: Master Degree or equivalent

    Physics: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut Galien Paris-Saclay
  • Organisation Type: Public Research Institution
  • Website: https:// www. umr-cnrs8612.u-psud.fr/
  • Country: France
  • City: CHATENAY MALABRY
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