Organisation/Company: CEA Evry
Research Field: Biological sciences › Other
Researcher Profile: Leading Researcher (R4) Established Researcher
Application Deadline: 30/11/2022 01:00 - Europe/London
Location: France › France
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Description of the Institution
The French Atomic Energy and Alternative Energies Commission (CEA) is a
public research organization. As a major player in research, development and
innovation, the CEA operates within the framework of its four missions:
defense and security
nuclear energy (fission and fusion)
technological research for industry
fundamental research (material sciences and life sciences).
The CEA has 16,000 employees – technicians, engineers, researchers, and
research support staff.
The François Jacob Institute of Biology in Evry (30 km south of Paris)
groups two departments: Genoscope – National Sequencing Center and the
National Center of Human Genomics Research. These departments combine high-
speed data production for highly competitive collaborative projects and own
research projects. The Genoscope – National Sequencing Center (previously
involved in the Human Genome Project), has among its missions to develop
methods, test technologies, and implement large-scale sequencing units for
genomics. The production and wet-lab development activities for sequencing are
carried out by the Sequencing Laboratory, which is composed by a team of
highly-skilled technicians and scientists. This unit feeds both our own
projects in bioinformatics analysis and research for new enzymatic functions,
and activities in collaboration with the national community, in particular
through the France Génomique program and with the Tara Ocean foundation.
The Genomics R&D Specialist will apply scientific domain-specific knowledge in
second and third-generation sequencing technologies and specialized data
processing techniques to design, develop and implement new sequencing
strategies in Environmental Genomics. The role will work in partnership with
scientists and lab technicians to support the generation of innovative
solutions, within defined project scopes and aligned to established
frameworks, which support decision-making in research, development and
In particular, we are seeking a Genomics researcher with strong desire to be a
key contributor for establishing/developing/testing innovative sequencing
strategies, while exploring new tools and methods to enable the analysis of
DNA/RNA sequence and epigenetic data in support of our R&D projects. You will
join us at the Sequencing Laboratory (SeqLab) at Genoscope (French National
Sequencing Centre). The latter has a long-standing tradition in the broad
field of genomics and was one of the key players in the Human Genome Project.
The candidate will benefit from a highly dynamic and interdisciplinary
environment, including biologists, microbiologists, computer scientists, and
bioinformaticians. You will partner with SeqLab scientists, interact across
the Production and Development units, and use wet-lab and computational
approaches to leverage cutting-edge genomics assays (e.g.: Oxford Nanopore
‘Read-Until', meta-omics with long-reads, detection of non-traditional
epigenetic marks). The position is a rare opportunity to work in a variety of
wet-lab and computational approaches relating to genomics/epigenomics and
interact with key stakeholders, while publishing and contributing directly to
the development of the field.
Drive hypothesis generation by applying wet-lab, sequencing approaches,
data integration, and biological knowledge.
Build and/or implement new sequencing strategies to translate biological
data into insights.
Identify and proactively help build strategic directions in long-read
Process troubleshooting throughout the entire sequencing workflow
(nucleic acid isolation, library preparation, sequencing and analysis).
REQUIRED EDUCATION LEVEL
Biological sciences: PhD or equivalent
A Master's degree in Biology or related field (e.g., Biological sciences,
Microbiology, Genetics), preferably with doctoral or equivalent
experience in Genomics/Epigenomics.
Demonstrated experience in multiple areas in at least three of the
following: long-read sequencing technologies (Pacbio/Nanopore), gene
expression analysis, epigenomics, Hi-C data analysis.
Demonstrated expertise in R, Python, or Perl. Experience in working on
high performance computing/cluster platforms.
Demonstrated experience in the use of many bioinformatics tools relating
to genomic (DNA/RNA) sequence analysis.
A keen demonstrated interest in translating genomic knowledge into
applications that leverage the field.
Organisation/Company: CEA Evry
Department: Genoscope - SeqLab
Organisation Type: Large Company
Website: https: // www. cea.fr/english
Postal Code: 91000
Street: 2 Rue Gaston Crémieux