Genomics R&D Specialist

Universities and Institutes of France

France

November 30, 2022

Description

  • Organisation/Company: CEA Evry
  • Research Field: Biological sciences › Other
  • Researcher Profile: Leading Researcher (R4) Established Researcher (R3)
  • Application Deadline: 30/11/2022 01:00 - Europe/London
  • Location: France › France
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Description of the Institution

    The French Atomic Energy and Alternative Energies Commission (CEA) is a public research organization. As a major player in research, development and innovation, the CEA operates within the framework of its four missions:

  • defense and security
  • nuclear energy (fission and fusion)
  • technological research for industry
  • fundamental research (material sciences and life sciences).
  • The CEA has 16,000 employees – technicians, engineers, researchers, and research support staff.

    Unit Description

    The François Jacob Institute of Biology in Evry (30 km south of Paris) groups two departments: Genoscope – National Sequencing Center and the National Center of Human Genomics Research. These departments combine high- speed data production for highly competitive collaborative projects and own research projects. The Genoscope – National Sequencing Center (previously involved in the Human Genome Project), has among its missions to develop methods, test technologies, and implement large-scale sequencing units for genomics. The production and wet-lab development activities for sequencing are carried out by the Sequencing Laboratory, which is composed by a team of highly-skilled technicians and scientists. This unit feeds both our own projects in bioinformatics analysis and research for new enzymatic functions, and activities in collaboration with the national community, in particular through the France Génomique program and with the Tara Ocean foundation.

    Job Description

    The Genomics R&D Specialist will apply scientific domain-specific knowledge in second and third-generation sequencing technologies and specialized data processing techniques to design, develop and implement new sequencing strategies in Environmental Genomics. The role will work in partnership with scientists and lab technicians to support the generation of innovative solutions, within defined project scopes and aligned to established frameworks, which support decision-making in research, development and sequencing activities.

    In particular, we are seeking a Genomics researcher with strong desire to be a key contributor for establishing/developing/testing innovative sequencing strategies, while exploring new tools and methods to enable the analysis of DNA/RNA sequence and epigenetic data in support of our R&D projects. You will join us at the Sequencing Laboratory (SeqLab) at Genoscope (French National Sequencing Centre). The latter has a long-standing tradition in the broad field of genomics and was one of the key players in the Human Genome Project. The candidate will benefit from a highly dynamic and interdisciplinary environment, including biologists, microbiologists, computer scientists, and bioinformaticians. You will partner with SeqLab scientists, interact across the Production and Development units, and use wet-lab and computational approaches to leverage cutting-edge genomics assays (e.g.: Oxford Nanopore ‘Read-Until', meta-omics with long-reads, detection of non-traditional epigenetic marks). The position is a rare opportunity to work in a variety of wet-lab and computational approaches relating to genomics/epigenomics and interact with key stakeholders, while publishing and contributing directly to the development of the field.

    Responsibilities

  • Drive hypothesis generation by applying wet-lab, sequencing approaches, data integration, and biological knowledge.
  • Build and/or implement new sequencing strategies to translate biological data into insights.
  • Identify and proactively help build strategic directions in long-read sequencing.
  • Process troubleshooting throughout the entire sequencing workflow (nucleic acid isolation, library preparation, sequencing and analysis).
  • Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

    Skills/Qualifications

    Essential Requirements

  • A Master's degree in Biology or related field (e.g., Biological sciences, Microbiology, Genetics), preferably with doctoral or equivalent experience in Genomics/Epigenomics.
  • Demonstrated experience in multiple areas in at least three of the following: long-read sequencing technologies (Pacbio/Nanopore), gene expression analysis, epigenomics, Hi-C data analysis.
  • Demonstrated expertise in R, Python, or Perl. Experience in working on high performance computing/cluster platforms.
  • Demonstrated experience in the use of many bioinformatics tools relating to genomic (DNA/RNA) sequence analysis.
  • A keen demonstrated interest in translating genomic knowledge into applications that leverage the field.
  • Contact Information
  • Organisation/Company: CEA Evry
  • Department: Genoscope - SeqLab
  • Organisation Type: Large Company
  • Website: https: // www. cea.fr/english
  • E-Mail: seqlab.info@henoscope.cns.fr
  • Country: France
  • City: Evry
  • State/Province: NA
  • Postal Code: 91000
  • Street: 2 Rue Gaston Crémieux
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