Factors Modulating Influenza Virus Emergence

Universities and Institutes of France

France

November 1, 2021

Description

  • Organisation/Company: UMR 1225 Interactions Hôtes - Agents Pathogènes (IHAP) de l'INRAE
  • Research Field: Biological sciences › Biology Medical sciences
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Leading Researcher (R4)
  • Application Deadline: 01/11/2021 00:00 - Europe/Athens
  • Location: France › Toulouse
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Offer Starting Date: 03/01/2022
  • Avian influenza viruses have the capacity to evolve genetically and to jump the species barrier to adapt to humans. These viruses have thus the potential to trigger future pandemics. The goal of the PhD project is to investigate which factors modulate influenza virus evolution and thus their ability to become more pathogenic or be more easily transmitted between individuals. More specifically, we will investigate how, within a host, a newly emerged variant interacts with its ancestor. We hypothesize that the interaction between viral variants within a host is a critical determinant of virus evolution. Therefore, developing knowledge on this subject will help prevent the emergence of new viruses of concern.

    The project will be based on the generation of viral variants by reverse- genetics and the analysis of their replication in various cell culture models and in animal models. Training will be provided for work in BSL2 and BSL3 laboratories and in various techniques (molecular biology, deep sequencing, bioinformatics).

    The PhD studentship is funded for 36 months by Région Occitanie and Agreenium and includes a monthly gross salary of 1758€. Staring date is 1/01/2022.

    Recent work in this field

    1. Figueroa T, Bessière P, Coggon A, Bouwman KM, van der Woude R, Delverdier M, Verheije MH, de Vries RP, Volmer R. 2020. The Microbiota Contributes to the Control of Highly Pathogenic H5N9 Influenza Virus Replication in Ducks. J Virol 94.

    2. Bessière P, Figueroa T, Coggon A, Foret-Lucas C, Houffschmitt A, Fusade- Boyer M, Dupré G, Guérin J-L, Delverdier M, Volmer R. 2021. Host factors drive the within-host competition between highly and low pathogenic H5N8 avian influenza viruses.

    3. Bessière P, Volmer R. 2021. From one to many: The within-host rise of viral variants. PLOS Pathog 17:e1009811.

    Funding category: Financement public/privé

    Funded studentship - Région Occitanie and Agreenium

    PHD Country: France

    Offer Requirements Specific Requirements

    We are looking for a student with a Master diploma, with a deep interest in viral evolution, with solid background in molecular biology and able to integrate knowledge from broad scientific fields.

    Contact Information
  • Organisation/Company: UMR 1225 Interactions Hôtes - Agents Pathogènes (IHAP) de l'INRAE
  • Organisation Type: Other
  • Website: https: // envt.fr/uniterecherche/test-5/
  • Country: France
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