Research Field: Medical sciences › Medicine
Researcher Profile: Recognised Researcher (R2)
Application Deadline: 15/12/2021 23:00 - Europe/London
Location: Portugal › Lisboa
Type Of Contract: To be defined
Job Status: Full-time
Hours Per Week: 40
Eu Research Framework Programme: H2020 / ERC
iMM is looking for a motivated post-doc to join the Gomes Lab at iMM-Lisbon,
funded by a European Research Council (ERC) Synergy Grant. The position
represents an exciting opportunity to work as part of a collaborative ERC
synergy grant with Michael Way (the Francis Crick Institute, London) and
Carolyn Moores (Birkbeck, London) to investigate the molecular, cellular and
physiological diversity of the Arp2/3 complex.
The Arp2/3 complex consisting of seven protein subunits is essential to
stimulate dynamic branched actin networks during multiple fundamental cellular
processes. The Way lab previously demonstrated that Arp2/3 subunit composition
dramatically affects the formation and stability of branched actin networks
(Abella et al., 2016). Moreover, the Gomes lab demonstrated that specific
Arp2/3 isoforms are essential for normal muscle development, specifically the
position of the nucleus in the periphery of the myofibers and the formation of
muscle triads (Roman et al. 2017).
The proposed project, which involves a close and interactive collaboration
with the labs of Carolyn Moores (Birkbeck, London) and Michael Way (Crick,
London), will use structural, biochemical and cellular approaches to
understand the regulation and properties of the eight different human Arp2/3
complexes during muscle development and regeneration. The successful
candidate(s) will be expected to drive their own independent research
programme using high resolution microscopy in combination with biochemistry,
optogenetics and molecular biology approaches.
Abella et al., Nature Cell Biol 2016
Roman et al., Nature Cell Biol 2017
Roman et al., Science 2021
For more information on the Gomes laboratory, please visit our website here.
Host Institution :
The iMM is a leading Portuguese biomedical research institute, that aims to
nurture innovative ideas in basic, translational and clinical research, with
the mission of improving human life through the study of disease mechanisms
and the development of novel predictive/diagnostic tests and therapeutic
Research in Portugal:
“In the western tip of Europe, you will find a country at the forefront of
technological developments with the perfect combination of European cultural
traditions, an eight centuries-old history, a pleasing lifestyle and the most
welcoming people.” (from www. study-research.pt video here)
Please send the following documents to firstname.lastname@example.org until
the 15th of December.
- Cover letter (please include contacts of at least two references).
- CV including major achievements.
Web site for additional job details
https: // imm.medicina.ulisboa.pt/pt-pt/emprego/#jobs
Curiosity to understand how the cytoskeleton controls cell organization
and membrane contact sites.
Imagination to decipher how organelle connections mediate cellular
Capacity to work in a multi-disciplinary team.
Experience with in vitro and/or in vivo fluorescent microscopy experience
Mouse cell biology and/or physiology experience (preferential).
Organisation Type: Research Laboratory
Website: https: // imm.medicina.ulisboa.pt
Postal Code: 1649-028
Street: Av. Prof. Egas Moniz, Ed. Egas Moniz