Doctoral Student In Medical Science - Tissue Resident Memory B Cells

Göteborg University

Sweden

May 30, 2022

Description

The University of Gothenburg tackles society's challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Doctoral position in Medical Science

Project title: Establishment, specificity and protective role of resident memory B cells at mucosal tissues

The Department of Microbiology and Immunology is located at the Institute of Biomedicine at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg.

General information about being a doctoral student at the University of Gothenburg can be found on the university's doctoral student pages: https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true

Duties

The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies

The doctoral project will investigate origin, specificity, formation and protective role of mucosal resident memory cells after infection. Viral respiratory infections caused by influenza-, orthopneumo- or corona-virus are major concerns worldwide. Influenza A virus (IAV) is a highly prevalent respiratory virus that causes significant morbidity and mortality in humans. Recently, few studies identified lung memory B cells (Bmem) as critical in preventing IAV reinfection. These tissue resident Bmem appear to have a broader specificity compared to splenic Bmem. Finally, our recent study demonstrated an incredible heterogeneity in Bmem, contrary to the focused serum Ab response we reported previously, yet Bmem epitope-specificity has not been elucidated. A better appreciation of tissue resident Bmem after infection and vaccination is crucial first step in developing mucosal vaccines against respiratory viruses.

By combining BCR sequencing with epitope mapping the student will define origin and clonal relationship of tissue resident memory B cells in respiratory mucosal tissues. With transfer experiments and fate mapping the student will determine the reactivation, differentiation and relative protection of the different subsets. The project will combine in vivo mouse experiments with in vitro immunological assays. The student will map formation and maintenance of memory B cells at mucosal tissues using in vivo infection, complex mouse-models, high-parameter flow cytometry and single cell RNA and BCR sequencing. Microscopy of infected mucosal tissues to identify localization of B cells will also be applied.

Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.

Eligibility

Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.

The general eligibility requirements for education at third-cycle level are: 1. having completed a degree at second-cycle level, or 2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad.

Specific entry requirements for this subject, according to the general syllabus, are: having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.

Assessment criteria

The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications: - specific knowledge and skills within the subject area and related research fields - experience of scientific theory and relevant research methodology - scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Documented experience within immunology, B cell biology and virology is a merit. Documented previous experience with in vivo animal work (including genotyping), multicolor flow cytometry, ELISPOT and in vitro B cell culture are strong merits.

Employment

Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.

Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Microbiology and Immunology. Extent: 100%. First day of employment: as agreed.

The University applies a local agreement on salaries for doctoral students.

Contact information

For more information about the project please contact the principal supervisor, Davide Angeletti, Associate Professor, Institute of Biomedicine, e-post: davide.angeletti@gu.se

Unions

Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Application

You can apply to be admitted for education at third-cycle level via the University of Gothenburg's recruitment portal. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
  • If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier .

    If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

    For information on what you need to submit in order to fulfill the English language requirement see https: // www. universityadmissions.se/en/entry- requirements/english-language-requirements/

    Applications must be received by: 2022-05-30

    Information for International Applicants

    Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

    https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/

    The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

    Salaries are set individually at the University.

    In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

    In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

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