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Doctoral position in Medical Science
Project title: Function and utility of Tcell markers in early rheumatoid
arthritis and anti-PD1 induced arthritis
The Department of Rheumatology and Inflammation Research is located at the
Institute of Medicine at the Faculty of Medicine at Sahlgrenska Academy,
University of Gothenburg. Inflammation is the main topic of the research
conducted within the Department. Our research groups perform studies of
inflammatory diseases, whether caused by allergy, infection, or autoimmune
disease. The goal is to investigate the mechanisms underlying the body's
tissues become inflamed. Many of our researchers are also working as a
specialist physician at the clinic at Sahlgrenska University Hospital, which
is also one of our greatest assets.
General information about being a doctoral student at the University of
Gothenburg can be found on the university's doctoral student pages:
https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true
The PhD education in Medical Science comprises carrying out a scientific
project and completing at least 30 credits of courses at third-cycle level.
The doctoral student must also write a scientific compilation thesis or
monograph corresponding to at least 120 credits. For more information about
third-cycle studies at Sahlgrenska Academy, see
https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Rheumatoid arthritis is a chronic autoimmune disease characterized by
inflammation in the synovia that can lead to destruction of cartilage and bone
if the disease is not treated early and with optimal therapy. Treatment of
cancer with the immune checkpoint inhibitor anti-PD1 can lead to development
of inflammatory arthritis that resembles rheumatoid arthritis. There are
multiple gaps of knowledge regarding the function and utility of PD1 in these
rheumatologic diseases. Our hypotheses are that PD1-positive T cells and
soluble PD1 can be used to predict treatment response in early RA, and that
PD1-positive T cells and soluble PD1 have a pathogenetic role in anti-PD1
induced arthritis. We can address these questions by clinical and experimental
data from two unique patient cohorts. The first is the NORD-STAR study, a
large Nordic randomized treatment study in untreated early RA, and the second
is a longitudinal cohort of patients with arthritis induced by anti-PD1
treatment at Rheumatology and Oncology, Sahlgrenska University Hospital.
This PhD project is translational and include both immunological experimental
work with the use of samples from blood and joint from the patients as well as
analysis of clinical data from the cohorts in relation to PD1-related
biomarkers. We expect the results to provide methods for predicting effects of
specific treatments in early RA, and to provide knowledge on disease
mechanisms and biomarkers for risk of development of anti-PD1 induced
arthritis. The research group is led by Prof Anna Rudin who is main supervisor
and works both in a laboratory environment at Dept of Rheumatology and
inflammation research at Institute of Medicine, Sahlgrenska Academy, and at
Rheumatology clinic, Sahlgrenska University Hospital.
Education at third-cycle level comprises four years of full-time study, and
leads to a doctoral degree. As part of your employment as a doctoral student,
you may have departmental duties corresponding to up to 20 % of full-time
employment, distributed throughout your study period. Departmental duties
usually consist of teaching at first- and second-cycle levels, but may also
include research and administration.
Education at third-cycle level requires general eligibility and specific
eligibility as set out in the general syllabus for the subject.
The general eligibility requirements for education at third-cycle level are:
1. having completed a degree at second-cycle level, or
2. the fulfilment of course requirements totalling at least 240 credits, of
which at least 60 credits must be at second-cycle level, or
3. the acquisition of equivalent knowledge in some other way, either in
Sweden or abroad.
Specific entry requirements for this subject, according to the general
having completed the English B/6 course or is considered to have acquired
equivalent knowledge through previous studies.
The selection of applicants who are considered to have the ability required to
benefit from the study programme and who meet the general and specific
eligibility requirements are assessed based on the following documented
qualifications: - specific knowledge and skills within the subject area and related
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree
project, scientific journals or the like.
Once you have been admitted for education at third-cycle level, you will be
employed as a doctoral student at the University of Gothenburg. The provisions
for employment as a doctoral student can be found in ordinance SFS 1993:100.
Initial employment as a doctoral student may apply for a maximum of one year,
and may be renewed by a maximum of two years at a time. A doctoral student may
be employed as a doctoral student for a maximum of eight years, but the total
period of employment may not be longer than the equivalent of full-time
education at third-cycle level for four years.
Location: Sahlgrenska Academy, Institute of Medicine, Department of
Rheumatology and Inflammation Research. Extent: 100%. First day of employment:
The University applies a local agreement on salaries for doctoral students.
For more information about the project please contact the principal
Anna Rudin, Professor, Institute of Medicine,
phone: +46 701-424253, e-mail: firstname.lastname@example.org
Union representatives at the University of Gothenburg can be found here:
https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
You can apply to be admitted for education at third-cycle level via the
University of Gothenburg's recruitment portal. It is your responsibility to
ensure that the application is complete as per the vacancy notice, and that
the University receives it by the final application deadline.
You must include the following, in pdf format
Diploma and transcripts showing that you meet with the general entry
Proof of completion of English 6 course or the acquired equivalent
knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you
attach a diploma and full transcripts that makes assessing your degree easier
If your degree has not been verified by a Swedish authority you need to
provide contact details to the issuing university, registrar or similar, that
can verify the degree at our request.
For information on what you need to submit in order to fulfill the English
language requirement see https: // www. universityadmissions.se/en/entry-
Applications must be received by: 2022-06-14
Information for International Applicants
Choosing a career in a foreign country is a big step. Thus, to give you a
general idea of what we and Gothenburg have to offer in terms of benefits and
life in general for you and your family/spouse/partner please visit:
https: // www. gu.se/en/about-the-university/welcome-services
https: // www. movetogothenburg.com/
The University works actively to achieve a working environment with equal
conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden's regulations, the
University must archive application documents for two years after the
appointment is filled. If you request that your documents are returned, they
will be returned to you once the two years have passed. Otherwise, they will
In connection to this recruitment, we have already decided which recruitment
channels we should use. We therefore decline further contact with vendors,
recruitment and staffing companies.